Frequency of osteopenia in children and young adults with childhood-onset systemic lupus erythematosus
- PMID: 15986346
- DOI: 10.1002/art.21115
Frequency of osteopenia in children and young adults with childhood-onset systemic lupus erythematosus
Abstract
Objective: To determine the frequency of osteopenia in patients with childhood-onset systemic lupus erythematosus (SLE) compared with that in healthy matched controls, and to evaluate the relationship between disease-related variables and bone mineral mass.
Methods: Bone mineral density (BMD) and bone mineral content (BMC) were measured in a cohort of 70 patients with childhood-onset SLE (mean +/- SD disease duration 10.8 +/- 8.3 years, mean +/- SD age 26.4 +/- 9.9 years) and 70 age- and sex-matched healthy controls. BMD and BMC of the femoral neck, lumbar spine, total body, and distal one-third of the radius were measured by dual x-ray absorptiometry. We investigated the relationship between BMC and the following disease variables: cumulative dose of corticosteroids, organ damage, current use of corticosteroids, use of cyclophosphamide, age at disease onset, and disease activity at the time of diagnosis. Biochemical markers of bone metabolism were also measured.
Results: BMD values for the lumbar spine and femoral neck were significantly lower in patients than in healthy controls. The reduction in BMD of the lumbar spine was significantly greater than that of the total body. In multiple linear regression analyses, a higher cumulative corticosteroid dose was significantly associated with lower BMC of the lumbar spine and femoral neck. Decreased lumbar spine BMC was also related to male sex.
Conclusion: The frequency of osteopenia was higher in patients with childhood-onset SLE than in matched controls. The lumbar spine was the most seriously affected skeletal site, followed by the femoral neck. The cumulative dose of corticosteroids was shown to be an important explanatory variable for BMC values in the lumbar spine and femoral neck.
Similar articles
-
Childhood-onset disease carries a higher risk of low bone mineral density in an adult population of systemic lupus erythematosus.Rheumatology (Oxford). 2012 Mar;51(3):468-75. doi: 10.1093/rheumatology/ker306. Epub 2011 Nov 16. Rheumatology (Oxford). 2012. PMID: 22096013
-
Bone mineral density change in systemic lupus erythematosus: a 5-year followup study.J Rheumatol. 2014 Oct;41(10):1990-7. doi: 10.3899/jrheum.131190. Epub 2014 Jul 1. J Rheumatol. 2014. PMID: 24986848
-
Prevalence and etiology of low bone mineral density in juvenile systemic lupus erythematosus.Arthritis Rheum. 2007 Jun;56(6):1966-73. doi: 10.1002/art.22691. Arthritis Rheum. 2007. PMID: 17530722
-
Bone status in juvenile systemic lupus erythematosus.Lupus. 2007;16(8):580-6. doi: 10.1177/0961203307079040. Lupus. 2007. PMID: 17711892 Review.
-
Does birthweight predict bone mass in adulthood? A systematic review and meta-analysis.Osteoporos Int. 2011 May;22(5):1323-34. doi: 10.1007/s00198-010-1344-9. Epub 2010 Aug 4. Osteoporos Int. 2011. PMID: 20683711 Review.
Cited by
-
Early-onset lupus nephritis.Clin Kidney J. 2024 Jul 13;17(8):sfae212. doi: 10.1093/ckj/sfae212. eCollection 2024 Aug. Clin Kidney J. 2024. PMID: 39135943 Free PMC article. Review.
-
Evaluation of Bone Mineral Density in Juvenile Systemic Lupus Erythematosus.Arch Bone Jt Surg. 2023;11(12):777-782. doi: 10.22038/ABJS.2023.70697.3311. Arch Bone Jt Surg. 2023. PMID: 38146515 Free PMC article.
-
Managing Lupus Nephritis in Children and Adolescents.Paediatr Drugs. 2024 Mar;26(2):145-161. doi: 10.1007/s40272-023-00609-3. Epub 2023 Dec 20. Paediatr Drugs. 2024. PMID: 38117412 Review.
-
Low bone mineral density in Thai children with systemic lupus erythematosus: prevalence and risk factors.Asian Biomed (Res Rev News). 2021 Oct 29;15(5):245-250. doi: 10.2478/abm-2021-0030. eCollection 2021 Oct. Asian Biomed (Res Rev News). 2021. PMID: 37551322 Free PMC article.
-
Long-Term Outcomes of Children and Adolescents With Biopsy-Proven Childhood-Onset Lupus Nephritis.Kidney Int Rep. 2022 Oct 21;8(1):141-150. doi: 10.1016/j.ekir.2022.10.014. eCollection 2023 Jan. Kidney Int Rep. 2022. PMID: 36644360 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical