Identification of microRNAs of the herpesvirus family
- PMID: 15782219
- DOI: 10.1038/nmeth746
Identification of microRNAs of the herpesvirus family
Abstract
Epstein-Barr virus (EBV or HHV4), a member of the human herpesvirus (HHV) family, has recently been shown to encode microRNAs (miRNAs). In contrast to most eukaryotic miRNAs, these viral miRNAs do not have close homologs in other viral genomes or in the genome of the human host. To identify other miRNA genes in pathogenic viruses, we combined a new miRNA gene prediction method with small-RNA cloning from several virus-infected cell types. We cloned ten miRNAs in the Kaposi sarcoma-associated virus (KSHV or HHV8), nine miRNAs in the mouse gammaherpesvirus 68 (MHV68) and nine miRNAs in the human cytomegalovirus (HCMV or HHV5). These miRNA genes are expressed individually or in clusters from either polymerase (pol) II or pol III promoters, and share no substantial sequence homology with one another or with the known human miRNAs. Generally, we predicted miRNAs in several large DNA viruses, and we could neither predict nor experimentally identify miRNAs in the genomes of small RNA viruses or retroviruses.
Comment in
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Herpesviruses throw a curve ball: new insights into microRNA biogenesis and evolution.Nat Methods. 2005 Apr;2(4):252-4. doi: 10.1038/nmeth0405-252. Nat Methods. 2005. PMID: 15782215 No abstract available.
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Herpesviruses encode their own microRNAs.Clin Chem. 2014 May;60(5):791-2. doi: 10.1373/clinchem.2013.216408. Clin Chem. 2014. PMID: 24778302 No abstract available.
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