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Review
. 2004 Oct;3(10):853-62.
doi: 10.1038/nrd1523.

The role of the medicinal chemist in drug discovery--then and now

Joseph G Lombardino  1 , John A Lowe 3rd
Affiliations
Review

The role of the medicinal chemist in drug discovery--then and now

Joseph G Lombardino et al. Nat Rev Drug Discov. 2004 Oct.

Abstract

The role of the medicinal chemist in drug discovery has undergone major changes in the past 25 years, mainly because of the introduction of technologies such as combinatorial chemistry and structure-based drug design. As medicinal chemists with more than 50 years of combined experience spanning the past four decades, we discuss this changing role using examples from our own and others' experience. This historical perspective could provide insights in to how to improve the current model for drug discovery by helping the medicinal chemist regain the creative role that contributed to past successes.

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