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Case Reports
. 2004 Mar;6(1):37-40.
doi: 10.1111/j.1399-3062.2004.00039.x.

Deep sinus aspergillosis in a liver transplant recipient successfully treated with a combination of caspofungin and voriconazole

S Tsiodras  1 , R Zafiropoulou, J Giotakis, G Imbrios, A Antoniades, E K Manesis
Affiliations
Case Reports

Deep sinus aspergillosis in a liver transplant recipient successfully treated with a combination of caspofungin and voriconazole

S Tsiodras et al. Transpl Infect Dis. 2004 Mar.

Abstract

We describe the rare case of a diabetic patient who was successfully treated for cytomegalovirus viremia and leishmaniasis following liver transplantation for hepatitis C virus-related cirrhosis, but also developed invasive sinus Aspergillus infection, while still on liposomal amphotericin B (AmBisome). The patient refused radical surgery including eye enucleation, and received a combination of intravenous caspofungin and voriconazole, along with repeated, conservative, local surgical debridement. At follow-up, 15 months after the onset of sinusitis, the patient remains culture-negative, fully active, and without evidence of local recurrence.

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