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. 2004 Jun 1;189(11):2023-6.
doi: 10.1086/386308. Epub 2004 May 11.

Familial clustering of classic Kaposi sarcoma

Emma Guttman-Yassky  1 , Adina Cohen, Zippi Kra-Oz, Rachel Friedman-Birnbaum, Elli Sprecher, Neli Zaltzman, Eitan Friedman, Michael Silbermann, Dina Rubin, Shai Linn, Dennis Whitby, Osnat Gideoni, Shimon Pollack, Reuven Bergman, Ronit Sarid
Affiliations

Familial clustering of classic Kaposi sarcoma

Emma Guttman-Yassky et al. J Infect Dis. .

Abstract

It is widely accepted that there is a causal association between Kaposi sarcoma-associated herpesvirus (KSHV) and Kaposi sarcoma (KS). However, the majority of individuals infected with KSHV never develop KS. Here, we present a unique familial case of classic KS, in which the disease occurs in 4 siblings who have no recognized underlying immunodeficiency. We examine risk factors that could play a role in this condition, including KSHV infection, KSHV DNA load, genetic variants of KSHV, infection with additional viruses, interleukin-6-promoter polymorphism, and HLA genotype. We hypothesize that a genetic susceptibility to KS, in combination with KSHV infection, may play an important role in the presented familial case.

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