doi: 10.1126/science.1096781.
Identification of virus-encoded microRNAs
Affiliations
- PMID: 15118162
- DOI: 10.1126/science.1096781
Item in Clipboard
Identification of virus-encoded microRNAs
Science.
.
Free article
Abstract
RNA silencing processes are guided by small RNAs that are derived from double-stranded RNA. To probe for function of RNA silencing during infection of human cells by a DNA virus, we recorded the small RNA profile of cells infected by Epstein-Barr virus (EBV). We show that EBV expresses several microRNA (miRNA) genes. Given that miRNAs function in RNA silencing pathways either by targeting messenger RNAs for degradation or by repressing translation, we identified viral regulators of host and/or viral gene expression.
Similar articles
-
Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript.Nature. 2006 Jul 6;442(7098):82-5. doi: 10.1038/nature04836. Epub 2006 May 31. Nature. 2006. Retraction in: Nature. 2008 Jan 31;451(7178):600. doi: 10.1038/nature06621 PMID: 16738545 Retracted.
-
Identification and validation of the cellular targets of virus-encoded microRNAs.Methods Mol Biol. 2010;667:319-26. doi: 10.1007/978-1-60761-811-9_21. Methods Mol Biol. 2010. PMID: 20827543
-
Epstein-Barr virus (EBV)-encoded RNA promotes growth of EBV-infected T cells through interleukin-9 induction.Cancer Res. 2004 Aug 1;64(15):5332-7. doi: 10.1158/0008-5472.CAN-04-0733. Cancer Res. 2004. PMID: 15289339
-
Genetics of Epstein-Barr virus microRNAs.Semin Cancer Biol. 2014 Jun;26:52-9. doi: 10.1016/j.semcancer.2014.02.002. Epub 2014 Mar 3. Semin Cancer Biol. 2014. PMID: 24602823 Review.
-
MicroRNAs and viral infection.Mol Cell. 2005 Oct 7;20(1):3-7. doi: 10.1016/j.molcel.2005.09.012. Mol Cell. 2005. PMID: 16209940 Review.
Cited by
-
A glance at subgenomic flavivirus RNAs and microRNAs in flavivirus infections.Virol J. 2016 May 28;13:84. doi: 10.1186/s12985-016-0541-3. Virol J. 2016. PMID: 27233361 Free PMC article. Review.
-
Tinkering with translation: protein synthesis in virus-infected cells.Cold Spring Harb Perspect Biol. 2013 Jan 1;5(1):a012351. doi: 10.1101/cshperspect.a012351. Cold Spring Harb Perspect Biol. 2013. PMID: 23209131 Free PMC article. Review.
-
miRNA expression profiling of Epstein-Barr virus-associated NKTL cell lines by Illumina deep sequencing.FEBS Open Bio. 2016 Feb 27;6(4):251-63. doi: 10.1002/2211-5463.12027. eCollection 2016 Apr. FEBS Open Bio. 2016. PMID: 27239439 Free PMC article.
-
RNAi suppressor P19 can be broadly exploited for enhanced adenovirus replication and microRNA knockdown experiments.Sci Rep. 2013;3:1363. doi: 10.1038/srep01363. Sci Rep. 2013. PMID: 23455436 Free PMC article.
-
EBV-microRNAs as Potential Biomarkers in EBV-related Fever: A Narrative Review.Curr Mol Med. 2024;24(1):2-13. doi: 10.2174/1566524023666221118122005. Curr Mol Med. 2024. PMID: 36411555 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
