Review
doi: 10.1038/nrc904.
c-MYC: more than just a matter of life and death
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- PMID: 12360279
- DOI: 10.1038/nrc904
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Review
c-MYC: more than just a matter of life and death
Nat Rev Cancer.
2002 Oct.
Abstract
Deregulated expression of c-MYC occurs in a broad range of human cancers and is often associated with poor prognosis, indicating a key role for this oncogene in tumour progression. However, as established human tumours often bear multiple genetic lesions, it is difficult to determine whether c-MYC is instrumental in the initiation/progression of the tumour, or indeed whether inactivating c-MYC would lead to tumour regression. Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies.
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