Review
doi: 10.1016/s0958-1669(00)00153-1.
VEGF: an update on biological and therapeutic aspects
Affiliations
- PMID: 11102799
- DOI: 10.1016/s0958-1669(00)00153-1
Item in Clipboard
Review
VEGF: an update on biological and therapeutic aspects
Curr Opin Biotechnol.
2000 Dec.
Abstract
Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenic inducer as well as a mediator of vascular permeability. VEGF is essential for developmental angiogenesis and is also required for female reproductive functions and endochondral bone formation. Substantial evidence also implicates VEGF in tumors and intraocular neovascular syndromes. Currently, several clinical trials are ongoing to test the hypothesis that the inhibition of VEGF activity may be beneficial for these conditions.
Similar articles
-
The role of vascular endothelial growth factor in angiogenesis.Acta Haematol. 2001;106(4):148-56. doi: 10.1159/000046610. Acta Haematol. 2001. PMID: 11815711 Review.
-
Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications.Semin Oncol. 2002 Dec;29(6 Suppl 16):10-4. doi: 10.1053/sonc.2002.37264. Semin Oncol. 2002. PMID: 12516033 Review.
-
Divergence of angiogenic and vascular permeability signaling by VEGF: inhibition of protein kinase C suppresses VEGF-induced angiogenesis, but promotes VEGF-induced, NO-dependent vascular permeability.Arterioscler Thromb Vasc Biol. 2002 Jun 1;22(6):901-6. doi: 10.1161/01.atv.0000020006.89055.11. Arterioscler Thromb Vasc Biol. 2002. PMID: 12067896
-
Role of vascular endothelial growth factor in the regulation of angiogenesis.Kidney Int. 1999 Sep;56(3):794-814. doi: 10.1046/j.1523-1755.1999.00610.x. Kidney Int. 1999. PMID: 10469350 Review.
-
Vascular endothelial cell growth factor (VEGF), an emerging target for cancer chemotherapy.Curr Med Chem Anticancer Agents. 2003 Mar;3(2):95-117. doi: 10.2174/1568011033353452. Curr Med Chem Anticancer Agents. 2003. PMID: 12678905 Review.
Cited by
-
DPSCs treated by TGF-β1 regulate angiogenic sprouting of three-dimensionally co-cultured HUVECs and DPSCs through VEGF-Ang-Tie2 signaling.Stem Cell Res Ther. 2021 May 10;12(1):281. doi: 10.1186/s13287-021-02349-y. Stem Cell Res Ther. 2021. PMID: 33971955 Free PMC article.
-
Angiogenesis: a curse or cure?Postgrad Med J. 2005 Apr;81(954):236-42. doi: 10.1136/pgmj.2004.023309. Postgrad Med J. 2005. PMID: 15811887 Free PMC article. Review.
-
Human Umbilical Cord-Derived Mesenchymal Stem Cells Repair SU5416-Injured Emphysema by Inhibiting Apoptosis via Rescuing VEGF-VEGFR2-AKT Pathway in Rats.Int J Stem Cells. 2022 Nov 30;15(4):395-404. doi: 10.15283/ijsc21149. Epub 2022 Feb 28. Int J Stem Cells. 2022. PMID: 35220281 Free PMC article.
-
Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice.Neoplasia. 2009 Oct;11(10):1106-15. doi: 10.1593/neo.09934. Neoplasia. 2009. PMID: 19794969 Free PMC article.
-
Mathematical modeling of tumor-induced angiogenesis.J Math Biol. 2004 Aug;49(2):111-87. doi: 10.1007/s00285-003-0262-2. Epub 2004 Feb 6. J Math Biol. 2004. PMID: 15293017 Review. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
