doi: 10.1126/science.290.5489.142.
A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants
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- PMID: 11021800
- DOI: 10.1126/science.290.5489.142
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A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants
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Abstract
Posttranscriptional gene silencing (PTGS) is an ancient eukaryotic regulatory mechanism in which a particular RNA sequence is targeted and destroyed. The helper component-proteinase (HC-Pro) of plant potyviruses suppresses PTGS in plants. Using a yeast two-hybrid system, we identified a calmodulin-related protein (termed rgs-CaM) that interacts with HC-Pro. Here we report that rgs-CaM, like HC-Pro itself, suppresses gene silencing. Our work is the first report identifying a cellular suppressor of PTGS.
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