Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea
- PMID: 10437792
- DOI: 10.1016/s0014-5793(99)00891-1
Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea
Abstract
Three novel human sequences showing striking homology to the recently described bovine Ca2+/calmodulin kinase II-dependent epithelial chloride channel bCaCC have been identified in an expressed sequence tags database. Full-length clones were isolated using a 5' RACE approach. The encoded predicted proteins display 65% overall homology to bCaCC. Tissue expression patterns of the corresponding genes, designated as hCaCC-1, -2 and -3, appear to be highly restricted, with the first two genes primarily expressed in the digestive tract. Another original feature as compared to the CaCC family members is the fact that hCaCC-2 also shows expression in the brain. Taken together these findings demonstrate the existence of several CaCC-like genes in humans, some of which display distinct tissue specificity patterns within the CaCC subfamily of chloride channels.
Similar articles
-
Characterization of a murine gene homologous to the bovine CaCC chloride channel.Gene. 1999 Mar 4;228(1-2):181-8. doi: 10.1016/s0378-1119(98)00620-9. Gene. 1999. PMID: 10072771
-
Cloning of an epithelial chloride channel from bovine trachea.J Biol Chem. 1995 Dec 29;270(52):31016-26. doi: 10.1074/jbc.270.52.31016. J Biol Chem. 1995. PMID: 8537359
-
Cloning and characterization of lung-endothelial cell adhesion molecule-1 suggest it is an endothelial chloride channel.J Biol Chem. 1997 Oct 31;272(44):27853-61. doi: 10.1074/jbc.272.44.27853. J Biol Chem. 1997. PMID: 9346932
-
Structure and function of CLCA proteins.Physiol Rev. 2005 Jul;85(3):1061-92. doi: 10.1152/physrev.00016.2004. Physiol Rev. 2005. PMID: 15987802 Review.
-
Molecular characteristics and functional diversity of CLCA family members.Clin Exp Pharmacol Physiol. 2000 Nov;27(11):901-5. doi: 10.1046/j.1440-1681.2000.03358.x. Clin Exp Pharmacol Physiol. 2000. PMID: 11071307 Review.
Cited by
-
Frameshift Mutations and Loss of Expression of CLCA4 Gene are Frequent in Colorectal Cancers With Microsatellite Instability.Appl Immunohistochem Mol Morphol. 2020 Aug;28(7):489-494. doi: 10.1097/PAI.0000000000000777. Appl Immunohistochem Mol Morphol. 2020. PMID: 32773719 Free PMC article.
-
Murine mCLCA5 is expressed in granular layer keratinocytes of stratified epithelia.Histochem Cell Biol. 2010 Mar;133(3):285-99. doi: 10.1007/s00418-009-0667-0. Epub 2009 Dec 11. Histochem Cell Biol. 2010. PMID: 20012443
-
Expression analysis of the CLCA gene family in mouse and human with emphasis on the nervous system.BMC Dev Biol. 2009 Feb 11;9:10. doi: 10.1186/1471-213X-9-10. BMC Dev Biol. 2009. PMID: 19210762 Free PMC article.
-
Comparison of the properties of CLCA1 generated currents and I(Cl(Ca)) in murine portal vein smooth muscle cells.J Physiol. 2002 Feb 15;539(Pt 1):107-17. doi: 10.1113/jphysiol.2001.013170. J Physiol. 2002. PMID: 11850505 Free PMC article.
-
Messenger RNA expression of transporter and ion channel genes in undifferentiated and differentiated Caco-2 cells compared to human intestines.Pharm Res. 2003 Jan;20(1):3-15. doi: 10.1023/a:1022282221530. Pharm Res. 2003. PMID: 12608530
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous
