doi: 10.1126/science.284.5418.1372.
UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation
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- PMID: 10334995
- DOI: 10.1126/science.284.5418.1372
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UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation
Science.
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Abstract
Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.
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