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Proc Natl Acad Sci U S A. 1996 Jan 9; 93(1): 13–20.
doi: 10.1073/pnas.93.1.13
PMCID: PMC40170
PMID: 8552589

Principles of protein-protein interactions.

S Jones and J M Thornton
Author information Copyright and License information PMC Disclaimer

Abstract

This review examines protein complexes in the Brookhaven Protein Databank to gain a better understanding of the principles governing the interactions involved in protein-protein recognition. The factors that influence the formation of protein-protein complexes are explored in four different types of protein-protein complexes--homodimeric proteins, heterodimeric proteins, enzyme-inhibitor complexes, and antibody-protein complexes. The comparison between the complexes highlights differences that reflect their biological roles.

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Selected References

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