Learn more: PMC Disclaimer | PMC Copyright Notice
Viruses in sewage waters during and after a poliomyelitis outbreak and subsequent nationwide oral poliovirus vaccination campaign in Finland.
Abstract
During an outbreak of paralytic poliomyelitis in Finland in 1984 and 1985 the widespread circulation of the causative wild-type serotype 3 poliovirus in the population was documented by demonstrating the virus in sewage water specimens in 13 different locations in the greater Helsinki district and in 13 other cities or towns all over the country. After the nationwide campaign with oral poliovirus vaccine in 1985, poliovirus serotypes 2 and 3 were readily isolated from sewage waters for up to 2 months, whereas type 1 poliovirus seemed to disappear from the sewage more rapidly. All of these isolates were temperature sensitive and therefore most likely vaccine related. The efficacy of the vaccination campaign in regard to elimination of the epidemic type 3 strain was evaluated by a follow-up study on viruses in sewage waters continued for 12 months through the subsequent expected season of poliomyelitis. Several types of enteroviruses, including five vaccine-related poliovirus strains, were identified in the 72 virus-positive specimens out of 93 studied. No wild-type polioviruses were found, indicating the success of the campaign.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (708K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ferguson M, Yi-hua Q, Minor PD, Magrath DI, Spitz M, Schild GC. Monoclonal antibodies specific for the Sabin vaccine strain of poliovirus 3. Lancet. 1982 Jul 17;2(8290):122–124. [PubMed] [Google Scholar]
- Hovi T, Cantell K, Huovilainen A, Kinnunen E, Kuronen T, Lapinleimu K, Pöyry T, Roivainen M, Salama N, Stenvik M, et al. Outbreak of paralytic poliomyelitis in Finland: widespread circulation of antigenically altered poliovirus type 3 in a vaccinated population. Lancet. 1986 Jun 21;1(8495):1427–1432. [PubMed] [Google Scholar]
- Kinnunen E, Hovi T, Stenvik M. Outbreak of poliomyelitis in Finland in 1984. Description of nine cases with persisting paralysis. Scand J Infect Dis. 1986;18(1):15–18. [PubMed] [Google Scholar]