Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression

PMC full text:

Front Psychiatry. 2020; 11: 549749.

Published online 2020 Sep 11. doi: 10.3389/fpsyt.2020.549749

Table 2

Group difference of GABA/water.

AN(C)OVA
			FD-PDS-MDD				FD-PDS			HC			AN(C)OVA^a
			(n = 24)				(n = 24)			(n = 24)
ROI			mean		SD	mean			SD	Mean		SD	F	df	p	Bonferroni-corrected p
Left Dorsolateral Prefrontal Cortex^b			2.2		0.49	2.08			0.38	2.05		0.39	1.7	2, 1, 68	0.19	0.76
Left Insula			2.53		0.22	2.53			0.23	2.46		0.24	0.8	2, 69	0.46	>0.99
Bilateral Pregenual Anterior Cingulate			2.3		0.23	2.38			0.25	2.28		0.22	1.3	2, 69	0.28	>0.99
Left Somatosensory Cortex			2.28		0.33	2.34			0.22	2.33		0.23	0.4	2, 69	0.67	>0.99
Generalized Estimating Equation^c
ROI	Group	β		Z			p	Bonferroni-corrected p			95% CI
Left DLPFC	FD-PDS-MDD
	FD-PDS	-0.16		-1.26			0.21	0.84			0.85 (0.67-1.09)
	HC	-0.21		-1.63			0.1	0.4			0.81 (0.63-1.04)
Left Insula	FD-PDS-MDD
	FD-PDS	0.002		0.03			0.98	>0.99			1 (0.89-1.13)
	HC	-0.07		-1.02			0.31	>0.99			0.94 (0.82-1.06)
pgACC	FD-PDS-MDD
	FD-PDS	0.1		1.41			0.16	0.64			1.1 (0.96-1.27)
	HC	0.003		0.04			0.97	>0.99			1 (0.88-1.14)
Left SSC	FD-PDS-MDD
	FD-PDS	0.08		1.03			0.3	>0.99			1.09 (0.93-1.28)
	HC	0.1		1.1			0.27	>0.99			1.1 (0.93-1.31)

^aLevene's test confirmed equal variances across groups.

^bCovariate: IQ.

^cAdjusted for age, gray matter volume in same-region MRS ROI and IQ.