Nanomaterial Toxicity Testing in the 21st Century: Use of a Predictive Toxicological Approach and High Throughput Screening

ANDRE NEL; TIAN XIA; HUAN MENG; XIANG WANG; SIJIE LIN; ZHAOXIA JI; HAIYUAN ZHANG

doi:10.1021/ar300022h

Figure 9

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Predictive toxicological paradigm for fibrogenic effects of MWCNTs

Cellular assays were developed based on the synergistic cellular responses in the epithelial-mesenchymal trophic cell unit, which are predictive of the fibrogenic potential of MWCNTs in vivo. Well-dispersed MWCNTs induced more prominent pro-fibrogenic responses in vitro as well as in vivo than non-dispersed tubes.