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Acc Chem Res. Author manuscript; available in PMC 2014 May 27.
Published in final edited form as:
Acc Chem Res. 2013 Mar 19; 46(3): 607–621.
Published online 2012 Jun 7. doi: 10.1021/ar300022h
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Figure 9

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Predictive toxicological paradigm for fibrogenic effects of MWCNTs

Cellular assays were developed based on the synergistic cellular responses in the epithelial-mesenchymal trophic cell unit, which are predictive of the fibrogenic potential of MWCNTs in vivo. Well-dispersed MWCNTs induced more prominent pro-fibrogenic responses in vitro as well as in vivo than non-dispersed tubes.

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