Skip to main content
PMC home page
Journal of Virology logoLink to Journal of Virology
. 1990 Mar;64(3):1407–1409. doi: 10.1128/jvi.64.3.1407-1409.1990

Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization.

H Vennema 1, R J de Groot 1, D A Harbour 1, M Dalderup 1, T Gruffydd-Jones 1, M C Horzinek 1, W J Spaan 1
PMCID: PMC249267  PMID: 2154621

Abstract

The gene encoding the fusogenic spike protein of the coronavirus causing feline infectious peritonitis was recombined into the genome of vaccinia virus. The recombinant induced spike-protein-specific, in vitro neutralizing antibodies in mice. When kittens were immunized with the recombinant, low titers of neutralizing antibodies were obtained. After challenge with feline infectious peritonitis virus, these animals succumbed earlier than did the control group immunized with wild-type vaccinia virus (early death syndrome).

Full text

PDF
1407

Images in this article

1408Image
on p.1408
1409Image
on p.1409

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Halstead S. B. Pathogenesis of dengue: challenges to molecular biology. Science. 1988 Jan 29;239(4839):476–481. doi: 10.1126/science.3277268. [DOI] [PubMed] [Google Scholar]
  2. Pedersen N. C. Animal virus infections that defy vaccination: equine infectious anemia, caprine arthritis-encephalitis, maedi-visna, and feline infectious peritonitis. Adv Vet Sci Comp Med. 1989;33:413–428. doi: 10.1016/B978-0-12-039233-9.50017-2. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Pedersen N. C., Black J. W. Attempted immunization of cats against feline infectious peritonitis, using avirulent live virus or sublethal amounts of virulent virus. Am J Vet Res. 1983 Feb;44(2):229–234. [PubMed] [Google Scholar]
  4. Porterfield J. S. Antibody-dependent enhancement of viral infectivity. Adv Virus Res. 1986;31:335–355. doi: 10.1016/s0065-3527(08)60268-7. [DOI] [PubMed] [Google Scholar]
  5. Robinson W. E., Jr, Montefiori D. C., Mitchell W. M. Antibody-dependent enhancement of human immunodeficiency virus type 1 infection. Lancet. 1988 Apr 9;1(8589):790–794. doi: 10.1016/s0140-6736(88)91657-1. [DOI] [PubMed] [Google Scholar]
  6. Spaan W., Cavanagh D., Horzinek M. C. Coronaviruses: structure and genome expression. J Gen Virol. 1988 Dec;69(Pt 12):2939–2952. doi: 10.1099/0022-1317-69-12-2939. [DOI] [PubMed] [Google Scholar]
  7. Stoddart C. A., Scott F. W. Intrinsic resistance of feline peritoneal macrophages to coronavirus infection correlates with in vivo virulence. J Virol. 1989 Jan;63(1):436–440. doi: 10.1128/jvi.63.1.436-440.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Takeda A., Tuazon C. U., Ennis F. A. Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry. Science. 1988 Oct 28;242(4878):580–583. doi: 10.1126/science.2972065. [DOI] [PubMed] [Google Scholar]
  9. Vennema H., Heijnen L., Zijderveld A., Horzinek M. C., Spaan W. J. Intracellular transport of recombinant coronavirus spike proteins: implications for virus assembly. J Virol. 1990 Jan;64(1):339–346. doi: 10.1128/jvi.64.1.339-346.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Weiss R. C., Scott F. W. Antibody-mediated enhancement of disease in feline infectious peritonitis: comparisons with dengue hemorrhagic fever. Comp Immunol Microbiol Infect Dis. 1981;4(2):175–189. doi: 10.1016/0147-9571(81)90003-5. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Weiss R. C., Scott F. W. Pathogenesis of feline infectious peritonitis: nature and development of viremia. Am J Vet Res. 1981 Mar;42(3):382–390. [PubMed] [Google Scholar]
  12. Weiss R. C., Scott F. W. Pathogenesis of feline infetious peritonitis: pathologic changes and immunofluorescence. Am J Vet Res. 1981 Dec;42(12):2036–2048. [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES