Nature

Bioinformatics articles from across Nature Portfolio

Bioinformatics is a field of study that uses computation to extract knowledge from biological data. It includes the collection, storage, retrieval, manipulation and modelling of data for analysis, visualization or prediction through the development of algorithms and software.

Latest Research and Reviews

Meta-analysis of RNA-Seq datasets allows a better understanding of P. tricornutum cellular biology, a requirement to improve the production of Biologics
- Isabelle Boulogne
- Charlotte Toustou
- Muriel Bardor
ResearchOpen Access29 Jan 2025 Scientific Reports
Volume: 15, P: 3603
Dual modality feature fused neural network integrating binding site information for drug target affinity prediction
- Haohuai He
- Guanxing Chen
- Calvin Yu-Chian Chen
ResearchOpen Access28 Jan 2025 npj Digital Medicine
Volume: 8, P: 67
Single-cell transcriptomics of bronchoalveolar lavage during PRRSV infection with different virulence

Porcine reproductive and respiratory syndrome virus strains can have markedly different virulence in pigs. Here, the authors describe differences in the immune response to infection with varying virulence and suggest that M2-like macrophages may aid in recovery and lung health.
- Byeonghwi Lim
- Seung-Chai Kim
- Jun-Mo Kim
ResearchOpen Access28 Jan 2025 Nature Communications
Volume: 16, P: 1112
Next generation sequencing of multiple SARS-CoV-2 infections in the Omicron Era
- Marzia Cavalli
- Giulia Campoli
- Silvia Fillo
ResearchOpen Access27 Jan 2025 Scientific Reports
Volume: 15, P: 3372
Chromosome-level genome assembly of black carp Mylopharyngodon piceus using Nanopore and Hi-C technologies
- Yuxuan Zhang
- Yanwen Shao
- Runsheng Li
ResearchOpen Access25 Jan 2025 Scientific Data
Volume: 12, P: 145
Characterizing the omics landscape based on 10,000+ datasets
- Eva Brombacher
- Oliver Schilling
- Clemens Kreutz
ResearchOpen Access25 Jan 2025 Scientific Reports
Volume: 15, P: 3189

All Research & Reviews

News and Comment

AlphaFold 3 is great — but it still needs human help to get chemistry right
- Georg Steinkellner
- Wolfgang Kroutil
- Christian C. Gruber
Correspondence14 Jan 2025 Nature
Volume: 637, P: 548
Why a silly-sounding name suits the serious mission of our biotech spin-off

How do you choose what to call your company? Wobble Genomics’s chief executive, Richard Kuo, explains.
- Jacqui Thornton
Comments & Opinion13 Jan 2025 Nature
Unveiling potential threats: backdoor attacks in single-cell pre-trained models
- Sicheng Feng
- Siyu Li
- Shengquan Chen
CorrespondenceOpen Access30 Nov 2024 Cell Discovery
Volume: 10, P: 122
Balancing memory in sleep: firing barrages as a circuit breaker for reactivation
- Hayder Amin
Research HighlightsOpen Access22 Nov 2024 Signal Transduction and Targeted Therapy
Volume: 9, P: 328
A ‘Wikipedia for cells’: researchers get an updated look at the Human Cell Atlas, and it’s remarkable

Coming less than a decade after its launch, the studies emerging from the global project are a major achievement. Funders should sign up for the long haul.

Editorial20 Nov 2024 Nature
Volume: 635, P: 523-524
Harnessing deep learning to build optimized ligands

A recent study proposes DeepBlock, a deep learning-based approach for generating ligands with targeted properties, such as low toxicity and high affinity with the given target. This approach outperforms existing methods in the field while maintaining synthetic accessibility and drug-likeness.
- Orestis A. Ntintas
- Theodoros Daglis
- Vassilis G. Gorgoulis
News & Views14 Nov 2024 Nature Computational Science
Volume: 4, P: 809-810

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