In a new study, neoadjuvant immunotherapy led to major pathological responses in patients with locally advanced colon cancer harboring mismatch repair deficiency — and emerging evidence suggests that organ-sparing approaches may also be feasible.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Myriam, C. et al. N. Engl. J. Med. 390, 1949–1958 (2024).
Cercek, A. et al. N. Engl. J. Med. 386, 2363–2376 (2022).
Cercek, A. et al. J. Clin. Oncol. 42, LBA3512 (2024).
Ludford, K. et al. J. Clin. Oncol. 41, 2181–2190 (2023).
De La Fouchardiere, C. et al. J. Clin. Oncol. 41, 2591–2591 (2023).
Le, D. T. et al. Science 357, 409–413 (2017).
Cercek, A. et al. J. Natl. Compr. Canc. Netw. 12, 513–519 (2014).
Garcia-Aguilar, J. et al. J. Clin. Oncol. 40, 2546–2556 (2022).
Verschoor, Y. L. et al. J. Clin. Oncol. 40, 3511–3511 (2022).
Verschoor, Y. L. et al. Ann. Oncol. 34, S1270 (2023).
Chalabi, M. et al. Nat. Med. 26, 566–576 (2020).
Helmink, B. A. et al. Nature 577, 549–555 (2020).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
B.R. served in a consulting and/or advisory role for Neophor, and has received travel, accommodation and expenses from Bayer, Servier and Astellas outside of the current manuscript. A.C. served in a consulting and/or advisory role for Abbvie, Amgen, Pfizer/Seagen, Merck, GSK, Regeneron, Daiichi Sanko, Janssen and Illumina, and receives institutional research funding from GSK and Pfizer/Seagen. L.A.D. is a member of the board of directors of Quest Diagnostics and Epitope, is a compensated consultant to Innovatus, Seer, Delfi and Neophore and is an inventor of multiple licensed patents related to technology for circulating tumor DNA analyses and MMRd for diagnosis and therapy; some of these licenses and relationships are associated with equity or royalty payments to the inventors. L.A.D. also holds equity in Quest Diagnostics, Epitope, Seer, Delfi and Neophore, divested equity in Personal Genome Diagnostics to LabCorp in February 2022 and divested equity in Thrive Earlier Detection to Exact Biosciences in January 2021; his spouse holds equity in Amgen. The terms of all these arrangements are being managed by Memorial Sloan Kettering in accordance with their conflict-of-interest policy.
Rights and permissions
About this article
Cite this article
Rousseau, B., Cercek, A. & Diaz, L.A. From neoadjuvant to organ-sparing immunotherapy for colorectal cancer. Nat Med 30, 2407–2408 (2024). https://doi.org/10.1038/s41591-024-03182-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41591-024-03182-5
