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PubMed ID
MGI Ref. ID
Title
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Vol(Iss)Pg
Dennis K; Fan T; Geiman T; Yan Q; Muegge K
Lsh, a member of the SNF2 family, is required for genome-wide methylation.
  • Functional annotations (GO): 2
  • Genome features: 1
  • Phenotypic alleles: 1
  • Sequences: 1
Genes Dev
2001
15 (22) 2940-4
5.594321
Methylation patterns of the mammalian genome are thought to be crucial for development. The precise mechanisms designating specific genomic loci for methylation are not known. Targeted deletion of Lsh results in perinatal lethality with a rather normal development. We report here, however, that Lsh(-/-) mice show substantial loss of methylation throughout the genome. The hypomethylated loci comprise repetitive elements and single copy genes. This suggests that global genomic methylation is not absolutely required for normal embryogenesis. Based on the similarity of Lsh to other SNF2 chromatin remodeling proteins, it suggests that alteration of chromatin affects global methylation patterns in mice.

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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory