Translational Optical Imaging in Diagnosis and Treatment of Cancer

Stijn      Keereweer; Merlijn      Hutteman; Jeroen      D.F. Kerrebijn; Cornelis      J.H. van de Velde; Alexander      L. Vahrmeijer; Clemens      W.G.M. Lowik

doi:10.2174/138920112799436294

Abstract

In cancer imaging, many different modalities are used that each have their specific features, leading to the combined use of different techniques for the detection, staging and treatment evaluation of cancer. Optical imaging using near-infrared fluorescence light is a new imaging modality that has recently emerged in the field of cancer imaging. After extensive preclinical research, the first steps of translation to the clinical practice are currently being made. In this article, we discuss the preclinical and clinical results of near-infrared optical imaging for non-invasive detection and classification of tumors, therapy monitoring, sentinel lymph node procedures, and image-guided cancer surgery. Widespread availability of imaging systems and optical contrast agents will enable larger studies on their clinical benefit and can help establish a definitive role in clinical practice.

Keywords: Image-guided surgery, near-infrared fluorescence, optical imaging, translational research, preclinical and clinical results, visualizing anatomy, computed tomography (CT), magnetic resonance imaging (MRI), clinical practice, positron emission tomography (PET), single-photon-emission computed tomography (SPECT), image anatomical, hemoglobin, absorption coefficient, hypermetabolism