Abstract
Population growth in the last century has raised important social and economic questions. Thus, current methods of fertility control have been under debate for a long period. Birth rates are essentially dependent on several environmental and social factors but women, who are great users of contraceptives, play a major role. Regulation of male fertility has been widely studied in recent years with the aim of developing a new male contraceptive for further inclusion of men’s choice in family planning. Based on the ancient people techniques to control the birth rates, natural products appeared as a promising source for the development of a male contraceptive. Over the years, many plants and their main constituents have been studied in the search for their antifertility properties. Interestingly, some antispermatogenic effects have been reported. Herein, we will discuss the antispermatogenic properties of some natural products. We propose to discuss specific targets and sites of action of the selected natural products. Despite the advances in this field in the last years, the molecular mechanisms by which natural products can control fertility, need to be disclosed to develop an effective, reversible and safe male contraceptive and avoid undesired toxicity in other organs. To date, no natural-based male contraceptive is available in the commercial market, mostly due to the difficulty in reversing the effects of these products in male fertility.
Keywords: .Antispermatogenic, contraception, male fertility, natural products, spermatogenesis.
Call for Papers in Thematic Issues
Advances in the Diagnosis and Treatment of Head and Neck Disease
Head and neck diseases encompass a wide range of conditions affecting the oral cavity, pharynx, larynx, nasal passages, sinuses, salivary glands, and other structures of the head and neck region. These diseases can have significantly on essential function, such as breathing, swallowing, speaking, as well as the quality of life. ...read more
Common Mechanisms Underpinning Neurodevelopmental Disorders and Psychiatric Diseases
A growing number of large-scale epidemiologic studies have strongly suggested that common mechanisms may be shared by aberrant brain development and psychiatric disorders. There is now an appreciation of the synergic roles of genetic variants and environmental stress, which profoundly affect genome integrity and reshape brain development. This can lead ...read more
New Cell Death Regulation Drugs for Cardiovascular Diseases
Cardiovascular diseases are the leading cause of mortality worldwide, with aberrant cell death processes playing a crucial role in their pathogenesis. Cell death in these diseases encompasses not only well-studied forms of apoptosis but also includes a variety of complex modes such as mitochondrial permeability transition (MPT)-driven necrosis, entotic cell ...read more
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Current Bioactive Compounds
Current Cancer Drug Targets
Combinatorial Chemistry & High Throughput Screening
Current Cancer Therapy Reviews
Current Diabetes Reviews
Current Drug Safety
Current Drug Targets
Current Drug Therapy
Related Books
Andrographolide and its Analogs: Botanical Sources, Phytochemistry, Pharmacology, and Biotechnology
Anthocyanins: Pharmacology and Nutraceutical Importance
The Roles and Responsibilities of Clinical Pharmacists in Hospital Settings
Bioactive Compounds from Medicinal Plants for Cancer Therapy and Chemoprevention
Drug Addiction Mechanisms in the Brain
Software and Programming Tools in Pharmaceutical Research
Objective Pharmaceutics: A Comprehensive Compilation of Questions and Answers for Pharmaceutics Exam Prep
Medicinal Chemistry of Drugs Affecting Cardiovascular and Endocrine Systems
Advanced Pharmacy
Plant-derived Hepatoprotective Drugs
32
