Advances in the Molecular Pathogenesis of Inflammatory Bowel Disease.

Introduction

This thematic issue will emphasize the recent breakthroughs in the mechanisms of Inflammatory bowel disease (IBD) pathogenesis and devotes some understanding of both Crohn’s and ulcerative colitis. It is expected to include studies about cellular and genetic aspects, which help to precipitate the disease, and the immune system-gut microbiome relations that are much more complicated. The issue aims to include both work at a bench and that at the bedside focusing on understanding the mechanisms of inflammation, tissue destruction, and disease evolution in IBD patients. The scope is targeted towards Exploring Genetic Susceptibility, Understanding Immunological Dysregulation, Interaction of Gut Microbiota and Host, Molecular Pathways in Inflammation and Tissue Damage, Investigation of Biomarkers or Molecular Targets for Therapy, and Translating Research to Clinics.

Keywords

Inflammatory Bowel Disease , Genetic Susceptibility, Immune Dysregulation, Gut Microbiome, Chronic Inflammation, Molecular Therapeutics

Sub-topics

Ø  Role of Cytokines and Immune Mediators in IBD Pathogenesis

Ø  Microbial Dysbiosis and its Impact on Gut Immunity in IBD

Ø  Signaling Pathways Driving Chronic Inflammation in IBD

Ø  Autophagy and Cellular Stress Responses in IBD

Ø  Biomarkers for Disease Activity, Progression, and Therapy Response

Ø  Genomic Insights into IBD: Identifying Risk Genes and Mutations

Ø  Targeted Molecular Therapies: Advances in Biologics and Small Molecules for IBD