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1,000 results • Page 1 of 20
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186
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Forum: Best tools for predicting targets of newly synthesized drugs?
drug-targets
updated 7 days ago by 44k • written 7 days ago by • 0
16
votes
7
replies
593
views
7 follow
Forum: How the field has changed in the last 5 years, and 25 years (up to 2024)
bioinformatics biology
updated 7 days ago by 4.0k • written 8 days ago by ▴ 30
0
votes
0
replies
199
views
Forum: epitope-TCR binding prediction, vaccine design
vaccine epitope-TCR binding
21 days ago by Dara • 0
0
votes
0
replies
240
views
Forum: layoffs in biotech
layoff biotech
21 days ago by Dara • 0
25
votes
13
replies
947
views
6 follow
Forum: How to do datamining in bioinformatics
data-mining
updated 22 days ago by 4.5k • written 23 days ago by ▴ 70
18
votes
9
replies
788
views
6 follow
Forum: The Evolution of NGS: What’s New and What’s Next?
ngs
updated 27 days ago by 146k • written 4 weeks ago by 5.9k
10
votes
4
replies
496
views
Forum: Awesome awesomeness bioinformatics
bioinformatics Awesome
6 weeks ago by Juke34 8.8k
4
votes
4
replies
396
views
Forum: What companies do you recommend for targeted sequencing?
Targeted-sequencing
6 weeks ago by amy__ ▴ 190
2
votes
2
replies
396
views
Forum: A guide for beginners in bioinformatics
sequencing ngs
updated 6 weeks ago by 44k • written 6 weeks ago by • 0
7
votes
8
replies
4.5k
views
9 follow
Forum: Dentist interested in bioinformatics
career
updated 7 weeks ago by ★ 2.7k • written 7.8 years ago by ▴ 10
5
votes
18
replies
1.5k
views
Forum: Is "training", fine tuning, or overfitting on "external independent validation datasets" considered cheating or scientific misconduct?
tools scientific misconduct overfitting
10 weeks ago by ivicts ▴ 10
12
votes
5
replies
667
views
Forum: Books and Blogs guiding the programming practice in bioinformatic research?
R Python Programming
11 weeks ago by JustinZhang ▴ 120
9
votes
12
replies
973
views
7 follow
Forum: What bioinformatics codes would you use for performance benchmarking on a new system?
benchmarking
11 weeks ago by Dave Carlson ★ 1.9k
5
votes
2
replies
410
views
Forum: GPU-enabled bioinformatics
GPU
3 months ago by Dave Carlson ★ 1.9k
36
votes
12
replies
1.1k
views
11 follow
Forum: How to improve a bioinformatics study and paper so that it is not considered "too preliminary" by publishers and journals?
DEG journal
updated 3 months ago by 4.9k • written 3 months ago by ▴ 60
0
votes
0
replies
239
views
Forum: Advice on Entering the field of Bioinformatics in Canada
career
updated 3 months ago by 44k • written 3 months ago by • 0
6
votes
3
replies
597
views
Forum: leetcode for bioinformatics?
leetcode
updated 3 months ago by 4.9k • written 3 months ago by ★ 1.9k
43
votes
19
replies
74k
views
14 follow
Forum: Will A Masters In Bioinformatics Help Me In Getting A Job?
education career
updated 3 months ago by 44k • written 13.6 years ago by ▴ 50
6
votes
4
replies
483
views
Forum: Resume building projects to break into bioinformatics?
job-hunting career-change
updated 8 weeks ago by ★ 2.1k • written 3 months ago by ▴ 20
1
vote
2
replies
707
views
Forum: scRNA-seq: Do people eliminate housekeeping genes for the sake of increasing algorithmic efficiency (and this speed)?
housekeeping-genes scRNA-seq
updated 3 months ago by 44k • written 3 months ago by • 0
36
votes
14
replies
1.8k
views
9 follow
Forum: Good Bioinformatics Jokes/Puns?
bioinformatics
updated 3 months ago by 12k • written 4 months ago by ▴ 20
1
vote
1
reply
347
views
Forum: Looking for opinions on the MSc Computational Biology and Bioinformatics program at the University of Göttingen
masters germany
updated 4 months ago by 146k • written 4 months ago by • 0
0
votes
1
reply
181
views
Forum: Are bacterial 16s paralogs real, and do they bias microbiome analyses conducted with QIIME2?
QIIME paralog microbiome bias 16s
5 months ago by evozoa • 0
2
votes
6
replies
796
views
Forum: How do you make an original contribution to knowledge in applied bioinformatics?
thesis academia PhD
5 months ago by Edna • 0
1
vote
10
replies
817
views
Forum: Posts getting removed?
meta biostars
updated 5 months ago by 44k • written 5 months ago by ▴ 590
6
votes
1
reply
365
views
Forum: Mailing list for academic programs and positions
masters phd
updated 5 months ago by 44k • written 5 months ago by • 0
2
votes
2
replies
357
views
Forum: How Can BioJobs Lab Effectively Attract Top Talent and Employers in the Biotech Industry?
biotech
updated 5 months ago by ▴ 30 • written 5 months ago by • 0
9
votes
13
replies
1.6k
views
7 follow
Forum: Ideal PC configurations and operating system for bioinformatics laboratory
PC
updated 5 months ago by 20k • written 6 months ago by ▴ 10
0
votes
0
replies
318
views
Forum: Improvement on automatic annotation of single-cell RNA-seq data from the literature using LLM
annotation scRNA llm
6 months ago by yxwucq • 0
5
votes
2
replies
529
views
Forum: Bioinformatics: Where do I start
Sequencing
updated 6 months ago by 44k • written 6 months ago by ▴ 20
11
votes
7
replies
3.3k
views
Forum: Bioinformatician who was retaliated against after reporting discriminatory harassment - Please help me navigate getting out of the situation I'm in
Career advice
updated 6 months ago by ★ 2.7k • written 6 months ago by ▴ 10
1
vote
2
replies
625
views
Forum: VCF bulk handling
bcftools SnpEff WGS VEP VCF
6 months ago by Javier • 0
16
votes
10
replies
1.5k
views
6 follow
Forum: F*up Night style events for Bioinformatics ? Comment if you're interested!
mistakes
updated 7 months ago by 5.3k • written 7 months ago by ★ 2.4k
7
votes
2
replies
571
views
Forum: Can questions and answers on biostars be asked only in English? Can't I use Russian for example?
language
updated 7 months ago by 55k • written 7 months ago by • 0
0
votes
0
replies
276
views
Forum: Field of Study in Computational Biology
Genomics Computational-Biology PhD
updated 7 months ago by 44k • written 7 months ago by • 0
1
vote
3
replies
700
views
Forum: Development plan for a bioinformatics database developer/coder
developer
7 months ago by pixie@bioinfo ★ 1.5k
7
votes
8
replies
2.0k
views
Forum: Bioinformatics career transition
career forum
updated 7 months ago by ★ 18k • written 7 months ago by ▴ 20
4
votes
2
replies
700
views
Forum: Exploring Amino Acid Patterns in Proteins Through N-gram Analysis
protein CAFA5
7 months ago by Anatoly A. ▴ 10
6
votes
6
replies
1.0k
views
Forum: You have 3 days of zero obligations and expansive resources. What are you building?
hypothetical thought-experiment
7 months ago by jared.andrews07 ★ 18k
0
votes
0
replies
301
views
Forum: What other data types and pipelines you would like to see from the Genomics Data Commons (GDC)
gdc tcga genomics-data-commons
updated 8 months ago by 44k • written 8 months ago by ★ 1.2k
0
votes
2
replies
591
views
Forum: What's the state of the art in bacterial whole genome alignment?
whole genome alignment mauve
8 months ago by Dave Carlson ★ 1.9k
33
votes
12
replies
2.1k
views
7 follow
Forum: Nextflow and self-made pipelines opinion
nextflow pipeline data-analysis
8 months ago by karlaarz ▴ 110
5
votes
4
replies
817
views
Forum: Would reaching out to local labs and startups help with my career transition?
career volunteering
updated 8 months ago by 146k • written 8 months ago by ▴ 10
1
vote
2
replies
568
views
Forum: Exploring Career Reentry: Challenges and opportunities for Women After Maternity and Childcare Breaks
Maternity Career-Gap career-reentry
updated 8 months ago by 85k • written 8 months ago by ▴ 40
8
votes
7
replies
1.3k
views
6 follow
Forum: Tower Server configuration for NGS data analysis
NGS
updated 8 months ago by ▴ 130 • written 9 months ago by • 0
1
vote
0
replies
391
views
Forum: list of bioinformatics tools in cancer genomics
mutations CNA cancer genomics LOH
updated 8 months ago by 164k • written 8 months ago by ★ 1.4k
4
votes
2
replies
588
views
Forum: bulk seq vs. sc-seq
scATAC-seq ATAC-seq scRNAseq RNAseq
updated 8 months ago by ★ 6.9k • written 8 months ago by ▴ 10
8
votes
6
replies
3.1k
views
Forum: Demonstrating Exponential Growth In Pre-School
education
written 10.7 years ago by 10k
0
votes
0
replies
290
views
Forum: tutorial for carrier screening analyses?
carrier-screening
updated 9 months ago by 44k • written 9 months ago by ▴ 20
2
votes
3
replies
603
views
Forum: My Project
Project CLI MD-Simulations Molecular-docking
9 months ago by Ajay A Shettigar • 0
1,000 results • Page 1 of 20
Recent Votes
Comment: Comparing whole transcriptome under one condition to the transcriptomes under ot
Comment: Can VST be called Log2 expression in a paper?
Comment: Explanation of DESeq factor leveling
Explanation of DESeq factor leveling
Comment: Run mutltiple Fastq files on Hisat2
filterx : fast and efficient filter tool written in Rust for csv,fasta,fastq,gff,vcf,sam files.
Answer: how to install conda bcftools +fill-tags plugin ?
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Recent Replies
Answer: Compare Two Sigle-cell Sample for Differentially Expressed Genes (DEGs). How? by ATpoint 85k
> But How could I know if the difference comes from sample instead of sequencing runs or cohort-driven batch effect? You cannot. It's pe…
Comment: Comparing GSEA mutant data to wild type by conmul • 0
Sorry that it was unclear in the post. The data is all CRISPR gene effect scores from DepMap. The 'significant genes' as mentioned in the p…
Comment: How to determine whether it is 10x data by king • 0
Thank you for your answer, it's very inspiring.
Comment: Inquiry about depth of coverage and copy number variation by Chen • 0
Thanks Pierre, I was actually thinking about the duplicate PCR reads and didn't explain it properly. I have found a post mentioning that qu…
Comment: Can a read be aligned more than once? by GenoMax 146k
Yes a read can be aligned more than once (I don't specifically know about gam/gaf). It would be called a "multi-mapping" read. You could im…
Comment: Statistical test to be used for dataset by allingt • 0
The choice of test depends on the types of variables involved and the hypothesis you have. But most importantly on the question you want am…
Comment: dittoHeatmap; adding column labels on the heatmap by jared.andrews07 ★ 18k
I'd consider making a [block annotation](https://jokergoo.github.io/ComplexHeatmap-reference/book/heatmap-annotations.html#block-annotation…
Comment: Comparing GSEA mutant data to wild type by allingt • 0
What do you mean by "significant gene"? How did you perform GSEA and on how did you rank your genes for it? From guesswork I might initiall…
Comment: Genes of Interest in a Multi-Tissue Analysis by allingt • 0
The DESeq2 manual tells us that the object class of vst() output is a subclass of RangedSummarizedExperiment. I suspect the methods applica…
Comment: WGCNA: Why are my brown, yellow, and other modules not visible in the gene dendr by allingt • 0
Did you perform blockwise module detection by any chance? Are your results object's contents sorted in blocks?
Comment: Why does WGCNA use weighted correlation instead of Pearson correlation? by allingt • 0
The WGCNA implementation by Langfelder and Horvath provides various correlation methods to create the initial correlation matrix. I don't t…
Comment: dittoHeatmap; adding column labels on the heatmap by Varun Gupta ★ 1.3k
any idea, how can I display the labels Pre and POst on the top of the heatmap? I am looking at complexheatmap package as to how they displa…
Comment: How can I determine the p-value of genes within each identified module in WGCNA? by allingt • 0
What p-value do you mean? When and how did you calculate it?
Answer: What is a genomic range that would almost always get decent WGS coverage but is by i.sudbery 20k
What about some of the well known enhancer regions, the globin locus LCR? Likely to be highly sequenceable, and yet not on exome panels.
Answer: Using NumReads column of quants.genes.sf file to build DESeq2 input by i.sudbery 20k
One of the improvements that the using the `salmon` -> `tximport` -> `DESeq2` pipeline, over just a `counts`->`DESeq2` pipeline is the abil…
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