Sooner or later, most corporations reach a point where their ability to generate growth internally falls well short of the growth rates expected by the board and CEO and demanded by investors. As the chart “Sustaining Growth Is Hard to Do” shows, companies entering the Fortune 50 averaged 9% to 20% growth rates in revenues during the five years prior to entering this elite group and 29% the year they entered—often via a large acquisition. Unfortunately, 93% of these companies never achieved revenue growth levels above 2% again. The equity markets were completely unforgiving: The companies’ share prices fell by an average of 61% following these collapses.

A version of this article appeared in the May 2006 issue of Harvard Business Review.