diff --git a/.circleci/config.yml b/.circleci/config.yml
index ae53d041e86..d5e10f4f5f6 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -3,7 +3,7 @@ version: 2
 defaults: &defaults
   working_directory: ~/repo
   docker:
-    - image: pyodide/pyodide-env:17
+    - image: pyodide/pyodide-env:18
   environment:
     - EMSDK_NUM_CORES: 3
       EMCC_CORES: 3
diff --git a/.gitignore b/.gitignore
index 0a1c3411a68..d50e1a67159 100644
--- a/.gitignore
+++ b/.gitignore
@@ -19,6 +19,7 @@ build
 ccache
 cpython/downloads
 cpython/installs
+cpython/build.log
 docs/_build/
 emsdk/emsdk
 geckodriver.log
diff --git a/Dockerfile b/Dockerfile
index 49e6d718f11..82f05619c07 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -3,11 +3,13 @@ FROM python:3.9.5-slim-buster
 
 RUN apt-get update \
   && apt-get install -y --no-install-recommends \
-                  # building packages
-                  bzip2 ccache clang-format-6.0 cmake f2c g++ gfortran git make \
-                  patch pkg-config swig unzip wget xz-utils \
-                  # testing packages: libgconf-2-4 is necessary for running chromium
-                  libgconf-2-4 "chromium=90.*" \
+        # building packages
+        bzip2 ccache clang-format-6.0 cmake f2c g++ gfortran git make \
+        patch pkg-config swig unzip wget xz-utils \
+        autoconf autotools-dev automake texinfo dejagnu \
+        build-essential prelink autoconf libtool libltdl-dev \
+        # testing packages: libgconf-2-4 is necessary for running chromium
+        libgconf-2-4 "chromium=90.*" \
   && rm -rf /var/lib/apt/lists/*
 
 RUN pip3 --no-cache-dir install \
diff --git a/Makefile.envs b/Makefile.envs
index 7626b57f915..cfd88e3b9b6 100644
--- a/Makefile.envs
+++ b/Makefile.envs
@@ -42,6 +42,7 @@ export LDFLAGS_BASE=\
 	-s WASM=1 \
 	-std=c++14 \
 	-s LZ4=1 \
+	-L $(CPYTHONROOT)/installs/python-$(PYVERSION)/lib/ \
 	$(EXTRA_LDFLAGS)
 
 export CXXFLAGS_BASE=
@@ -49,15 +50,16 @@ export CXXFLAGS_BASE=
 export SIDE_MODULE_LDFLAGS=	$(LDFLAGS_BASE) -s SIDE_MODULE=1
 export MAIN_MODULE_LDFLAGS= $(LDFLAGS_BASE) -s MAIN_MODULE=1 \
 	-s EXPORTED_FUNCTIONS='["___cxa_guard_acquire", "__ZNSt3__28ios_base4initEPv", "_main"]' \
-	$(CPYTHONROOT)/installs/python-$(PYVERSION)/lib/libpython$(PYMINOR).a \
+	-lpython$(PYMINOR) \
+	-lffi \
+	-lsqlite3 \
+	-lbz2 \
+	-lstdc++ \
 	-s TOTAL_MEMORY=20971520 \
 	-s ALLOW_MEMORY_GROWTH=1 \
     --use-preload-plugins \
 	-s USE_FREETYPE=1 \
 	-s USE_LIBPNG=1 \
-	-L$(wildcard $(CPYTHONROOT)/build/sqlite*/.libs) -lsqlite3 \
-	$(wildcard $(CPYTHONROOT)/build/bzip2*/libbz2.a) \
-	-lstdc++ \
 	--memory-init-file 0 \
 
 export SIDE_MODULE_CXXFLAGS = $(CXXFLAGS_BASE)
@@ -73,5 +75,6 @@ export MAIN_MODULE_CFLAGS= $(CFLAGS_BASE) \
 		-I$(PYTHONINCLUDE)
 
 
+
 .output_vars:
 	set
diff --git a/cpython/Makefile b/cpython/Makefile
index 1bf9a417660..c3368af37f0 100644
--- a/cpython/Makefile
+++ b/cpython/Makefile
@@ -25,8 +25,11 @@ BZIP2TARBALL=$(ROOT)/downloads/bzip2-1.0.2.tar.gz
 BZIP2BUILD=$(ROOT)/build/bzip2-1.0.2
 BZIP2URL=https://sourceware.org/pub/bzip2/bzip2-1.0.2.tar.gz
 
+FFIBUILD=$(ROOT)/build/libffi
+LIBFFIREPO=https://github.com/hoodmane/libffi-emscripten
+LIBFFI_COMMIT=dd8318b543b92d038da4914fac42d34056a80c7d
 
-all: $(INSTALL)/lib/$(LIB)
+all: $(INSTALL)/lib/$(LIB) $(INSTALL)/lib/libffi.a
 
 
 $(INSTALL)/lib/$(LIB): $(BUILD)/$(LIB) remove_modules.txt
@@ -86,7 +89,7 @@ $(ZLIBBUILD)/.configured: $(ZLIBTARBALL)
 	touch $@
 
 
-$(SQLITEBUILD)/libsqlite3.la: $(SQLITETARBALL)
+$(INSTALL)/lib/libsqlite3.a: $(SQLITETARBALL)
 	[ -d $(ROOT)/build ] || (mkdir $(ROOT)/build)
 	tar -C $(ROOT)/build/ -xf $(SQLITETARBALL)
 	# sqlite fails to detect that popen is not available. We have to set it
@@ -96,18 +99,30 @@ $(SQLITEBUILD)/libsqlite3.la: $(SQLITETARBALL)
 		emconfigure ./configure CFLAGS="$(PYTHON_CFLAGS)" CPPFLAGS="-DSQLITE_OMIT_POPEN"; \
 		emmake make -j $${PYODIDE_JOBS:-3}; \
 	)
+	mkdir -p $(INSTALL)/lib/
+	cp $(SQLITEBUILD)/.libs/libsqlite3.a $(INSTALL)/lib/libsqlite3.a
 
 
-$(BZIP2BUILD)/libbz2.a: $(BZIP2TARBALL)
+$(INSTALL)/lib/libbz2.a: $(BZIP2TARBALL)
 	[ -d $(ROOT)/build ] || (mkdir $(ROOT)/build)
 	tar -C $(ROOT)/build/ -xf $(BZIP2TARBALL)
 	( \
 		cd $(BZIP2BUILD); \
 		emmake make -j $${PYODIDE_JOBS:-3} CC=emcc CFLAGS="$(PYTHON_CFLAGS) -D_FILE_OFFSET_BITS=64" AR=emar RANLIB=emranlib libbz2.a; \
 	)
-
-
-$(BUILD)/Makefile: $(BUILD)/.patched $(ZLIBBUILD)/.configured $(SQLITEBUILD)/libsqlite3.la $(BZIP2BUILD)/libbz2.a
+	mkdir -p $(INSTALL)/lib
+	cp $(BZIP2BUILD)/libbz2.a $(INSTALL)/lib/libbz2.a
+
+$(INSTALL)/lib/libffi.a :
+	rm -rf $(FFIBUILD)
+	git clone $(LIBFFIREPO) $(FFIBUILD) --shallow-exclude upstream-base
+	source $(PYODIDE_ROOT)/emsdk/emsdk/emsdk_env.sh
+	cd  $(FFIBUILD) && git checkout $(LIBFFI_COMMIT) && bash ./build.sh ; make install
+	cp $(FFIBUILD)/target/include/*.h $(BUILD)/Include/
+	mkdir -p $(INSTALL)/lib
+	cp $(FFIBUILD)/target/lib/libffi.a $(INSTALL)/lib/
+
+$(BUILD)/Makefile: $(BUILD)/.patched $(ZLIBBUILD)/.configured $(INSTALL)/lib/libsqlite3.a $(INSTALL)/lib/libbz2.a
 	cp config.site $(BUILD)/
 	( \
 		cd $(BUILD); \
@@ -118,14 +133,17 @@ $(BUILD)/Makefile: $(BUILD)/.patched $(ZLIBBUILD)/.configured $(SQLITEBUILD)/lib
 			  --without-pymalloc \
 			  --disable-shared \
 			  --disable-ipv6 \
-			  --without-gcc \
+			  --enable-optimizations \
 			  --host=wasm32-unknown-emscripten\
 			  --build=$(shell $(BUILD)/config.guess) \
 			  --prefix=$(INSTALL) ; \
 	)
 
 
-$(BUILD)/$(LIB): $(BUILD)/Makefile Setup.local
+$(BUILD)/Modules/Setup.local : Setup.local
+	cp Setup.local $(BUILD)/Modules/
+
+$(BUILD)/$(LIB): $(BUILD)/Makefile $(BUILD)/pyconfig.h $(BUILD)/Modules/Setup.local $(INSTALL)/lib/libffi.a
 	cp Setup.local $(BUILD)/Modules/
 	cat pyconfig.undefs.h >> $(BUILD)/pyconfig.h
 	( \
diff --git a/cpython/Setup.local b/cpython/Setup.local
index dffed255633..75e2221626c 100644
--- a/cpython/Setup.local
+++ b/cpython/Setup.local
@@ -18,6 +18,11 @@ _datetime _datetimemodule.c
 _heapq _heapqmodule.c
 _json _json.c
 _csv _csv.c
+
+CTYPES_FLAGS=-DHAVE_FFI_PREP_CIF_VAR=1 -DHAVE_FFI_PREP_CLOSURE_LOC=1 -DHAVE_FFI_CLOSURE_ALLOC=1
+_ctypes _ctypes/_ctypes.c _ctypes/callbacks.c _ctypes/callproc.c _ctypes/cfield.c _ctypes/stgdict.c $(CTYPES_FLAGS)
+_ctypes_test _ctypes/_ctypes_test.c
+
 unicodedata unicodedata.c
 _pickle _pickle.c
 parser parsermodule.c
diff --git a/cpython/patches/ctypes-dont-deref-function-pointer.patch b/cpython/patches/ctypes-dont-deref-function-pointer.patch
new file mode 100644
index 00000000000..5c648bba5cf
--- /dev/null
+++ b/cpython/patches/ctypes-dont-deref-function-pointer.patch
@@ -0,0 +1,35 @@
+From 3f11694d7587e782530118d176306eeb6eebf5d1 Mon Sep 17 00:00:00 2001
+From: Hood <hood@mit.edu>
+Date: Wed, 23 Jun 2021 13:47:30 -0700
+Subject: [PATCH] Don't dereference function pointer
+
+Ctypes thinks that the result of dlsym is a pointer to the function pointer, so
+it should call it like `result = (*f)(args)`. Probably this is true for the
+native dlsym, but our dlsym returns an index into the indirect call table
+"wasmTable", in particular it isn't even aligned like a pointer should be.
+This patch fixes it so that it calls it like `result = f(args)` instead.
+
+---
+ Modules/_ctypes/_ctypes.c | 6 +++++-
+ 1 file changed, 5 insertions(+), 1 deletion(-)
+
+diff --git a/Modules/_ctypes/_ctypes.c b/Modules/_ctypes/_ctypes.c
+index ceae67e..44f2d76 100644
+--- a/Modules/_ctypes/_ctypes.c
++++ b/Modules/_ctypes/_ctypes.c
+@@ -771,7 +771,11 @@ CDataType_in_dll(PyObject *type, PyObject *args)
+         return NULL;
+     }
+ #endif
+-    return PyCData_AtAddress(type, address);
++    CDataObject *ob = (CDataObject *)GenericPyCData_new(type, NULL, NULL);
++    if (ob == NULL)
++        return NULL;
++    *(void **)ob->b_ptr = address;
++    return (PyObject*)ob;
+ }
+ 
+ static const char from_param_doc[] =
+-- 
+2.17.1
+
diff --git a/cpython/patches/remove-duplicate-symbols-from-cfield.c.patch b/cpython/patches/remove-duplicate-symbols-from-cfield.c.patch
new file mode 100644
index 00000000000..cb523c0087e
--- /dev/null
+++ b/cpython/patches/remove-duplicate-symbols-from-cfield.c.patch
@@ -0,0 +1,49 @@
+From fc3b69f9afa779185a60834cf1817c22706edcd1 Mon Sep 17 00:00:00 2001
+From: Hood <hood@mit.edu>
+Date: Tue, 22 Jun 2021 20:12:45 -0700
+Subject: [PATCH] Remove duplicate symbols from cfield.c
+
+These symbols are already defined by libffi.
+---
+ Modules/_ctypes/cfield.c | 26 --------------------------
+ 1 file changed, 26 deletions(-)
+
+diff --git a/Modules/_ctypes/cfield.c b/Modules/_ctypes/cfield.c
+index 7ebd4ba..7a63ab7 100644
+--- a/Modules/_ctypes/cfield.c
++++ b/Modules/_ctypes/cfield.c
+@@ -1635,31 +1635,5 @@ typedef struct _ffi_type
+ } ffi_type;
+ */
+ 
+-/* align and size are bogus for void, but they must not be zero */
+-ffi_type ffi_type_void = { 1, 1, FFI_TYPE_VOID };
+-
+-ffi_type ffi_type_uint8 = { 1, 1, FFI_TYPE_UINT8 };
+-ffi_type ffi_type_sint8 = { 1, 1, FFI_TYPE_SINT8 };
+-
+-ffi_type ffi_type_uint16 = { 2, 2, FFI_TYPE_UINT16 };
+-ffi_type ffi_type_sint16 = { 2, 2, FFI_TYPE_SINT16 };
+-
+-ffi_type ffi_type_uint32 = { 4, INT_ALIGN, FFI_TYPE_UINT32 };
+-ffi_type ffi_type_sint32 = { 4, INT_ALIGN, FFI_TYPE_SINT32 };
+-
+-ffi_type ffi_type_uint64 = { 8, LONG_LONG_ALIGN, FFI_TYPE_UINT64 };
+-ffi_type ffi_type_sint64 = { 8, LONG_LONG_ALIGN, FFI_TYPE_SINT64 };
+-
+-ffi_type ffi_type_float = { sizeof(float), FLOAT_ALIGN, FFI_TYPE_FLOAT };
+-ffi_type ffi_type_double = { sizeof(double), DOUBLE_ALIGN, FFI_TYPE_DOUBLE };
+-
+-#ifdef ffi_type_longdouble
+-#undef ffi_type_longdouble
+-#endif
+-  /* This is already defined on OSX */
+-ffi_type ffi_type_longdouble = { sizeof(long double), LONGDOUBLE_ALIGN,
+-                                 FFI_TYPE_LONGDOUBLE };
+-
+-ffi_type ffi_type_pointer = { sizeof(void *), VOID_P_ALIGN, FFI_TYPE_POINTER };
+ 
+ /*---------------- EOF ----------------*/
+-- 
+2.17.1
+
diff --git a/cpython/patches/xfail-core-ctypes-tests-that-don-t-work.patch b/cpython/patches/xfail-core-ctypes-tests-that-don-t-work.patch
new file mode 100644
index 00000000000..2022236bdb8
--- /dev/null
+++ b/cpython/patches/xfail-core-ctypes-tests-that-don-t-work.patch
@@ -0,0 +1,65 @@
+From a4aec920c76ebcb8360350ff0046c7a0c74c0cf2 Mon Sep 17 00:00:00 2001
+From: Hood <hood@mit.edu>
+Date: Thu, 24 Jun 2021 14:55:10 -0700
+Subject: [PATCH] xfail core ctypes tests that don't work
+
+PyCode_SetExtra doesn't work and ctypes doesn't seem to work with variadic functions including PyUnicode_FromFormat/
+---
+ Lib/test/test_code.py    | 7 +++++--
+ Lib/test/test_unicode.py | 1 +
+ 2 files changed, 6 insertions(+), 2 deletions(-)
+
+diff --git a/Lib/test/test_code.py b/Lib/test/test_code.py
+index ac3dde7..d91a350 100644
+--- a/Lib/test/test_code.py
++++ b/Lib/test/test_code.py
+@@ -389,6 +389,7 @@ if check_impl_detail(cpython=True) and ctypes is not None:
+                               ctypes.c_voidp(100)), 0)
+ 
+         def test_free_called(self):
++            raise unittest.SkipTest("PyCode_SetExtra is broken")
+             # Verify that the provided free function gets invoked
+             # when the code object is cleaned up.
+             f = self.get_func()
+@@ -398,6 +399,7 @@ if check_impl_detail(cpython=True) and ctypes is not None:
+             self.assertEqual(LAST_FREED, 100)
+ 
+         def test_get_set(self):
++            raise unittest.SkipTest("PyCode_SetExtra is broken")
+             # Test basic get/set round tripping.
+             f = self.get_func()
+ 
+@@ -414,6 +416,7 @@ if check_impl_detail(cpython=True) and ctypes is not None:
+             del f
+ 
+         def test_free_different_thread(self):
++            raise unittest.SkipTest("Requires threading")
+             # Freeing a code object on a different thread then
+             # where the co_extra was set should be safe.
+             f = self.get_func()
+@@ -438,8 +441,8 @@ def test_main(verbose=None):
+     from test import test_code
+     run_doctest(test_code, verbose)
+     tests = [CodeTest, CodeConstsTest, CodeWeakRefTest]
+-    if check_impl_detail(cpython=True) and ctypes is not None:
+-        tests.append(CoExtra)
++    # if check_impl_detail(cpython=True) and ctypes is not None:
++    #     tests.append(CoExtra)
+     run_unittest(*tests)
+ 
+ if __name__ == "__main__":
+diff --git a/Lib/test/test_unicode.py b/Lib/test/test_unicode.py
+index 23508c5..a618e25 100644
+--- a/Lib/test/test_unicode.py
++++ b/Lib/test/test_unicode.py
+@@ -2521,6 +2521,7 @@ class CAPITest(unittest.TestCase):
+ 
+     # Test PyUnicode_FromFormat()
+     def test_from_format(self):
++        raise unittest.SkipTest("ctypes don't work with variadic C functions like PyUnicode_FromFormat")
+         support.import_module('ctypes')
+         from ctypes import (
+             c_char_p,
+-- 
+2.17.1
+
diff --git a/cpython/remove_modules.txt b/cpython/remove_modules.txt
index 75f9e3cd526..49163a3f1f0 100644
--- a/cpython/remove_modules.txt
+++ b/cpython/remove_modules.txt
@@ -1,5 +1,4 @@
 _osx_support.py
-ctypes
 curses
 dbm
 ensurepip
diff --git a/docs/project/changelog.md b/docs/project/changelog.md
index fee266898da..320d08d96f6 100644
--- a/docs/project/changelog.md
+++ b/docs/project/changelog.md
@@ -56,6 +56,9 @@ substitutions:
 - The standard library module `audioop` is now included, making the `wave`,
   `sndhdr`, `aifc`, and `sunau` modules usable. {pr}`1623`
 
+- Added support for `ctypes`.
+  {pr}`1656`
+
 ### Python / JS type conversions
 
 - {{ API }} {any}`pyodide.runPythonAsync` no longer automatically calls
diff --git a/emsdk/patches/0001-Throw-away-errors-in-minify_wasm_js.patch b/emsdk/patches/0001-Throw-away-errors-in-minify_wasm_js.patch
new file mode 100644
index 00000000000..95f95ca6e9f
--- /dev/null
+++ b/emsdk/patches/0001-Throw-away-errors-in-minify_wasm_js.patch
@@ -0,0 +1,36 @@
+From 310269ed630ead73e89e6bfc15e54e4c90959c95 Mon Sep 17 00:00:00 2001
+From: Hood <hood@mit.edu>
+Date: Thu, 24 Jun 2021 04:08:02 -0700
+Subject: [PATCH] Throw away errors in minify_wasm_js
+
+---
+ emcc.py | 13 ++++++++-----
+ 1 file changed, 8 insertions(+), 5 deletions(-)
+
+diff --git a/emsdk/upstream/emscripten/emcc.py b/emsdk/upstream/emscripten/emcc.py
+index 839f791b3..5653470dd 100755
+--- a/emsdk/upstream/emscripten/emcc.py
++++ b/emsdk/upstream/emscripten/emcc.py
+@@ -2901,11 +2901,14 @@ def do_binaryen(target, options, wasm_target):
+       # Closure can print out readable error messages (Closure will then
+       # minify whitespace afterwards)
+       save_intermediate_with_wasm('preclean', wasm_target)
+-      final_js = building.minify_wasm_js(js_file=final_js,
+-                                         wasm_file=wasm_target,
+-                                         expensive_optimizations=will_metadce(),
+-                                         minify_whitespace=minify_whitespace() and not options.use_closure_compiler,
+-                                         debug_info=intermediate_debug_info)
++      try:
++        final_js = building.minify_wasm_js(js_file=final_js,
++                                          wasm_file=wasm_target,
++                                          expensive_optimizations=will_metadce(),
++                                          minify_whitespace=minify_whitespace() and not options.use_closure_compiler,
++                                          debug_info=intermediate_debug_info)
++      except:
++        pass
+       save_intermediate_with_wasm('postclean', wasm_target)
+ 
+   if shared.Settings.ASYNCIFY_LAZY_LOAD_CODE:
+-- 
+2.17.1
+
diff --git a/packages/imageio/meta.yaml b/packages/imageio/meta.yaml
index 1114882fd7f..6eb38282714 100644
--- a/packages/imageio/meta.yaml
+++ b/packages/imageio/meta.yaml
@@ -4,8 +4,6 @@ package:
 source:
   sha256: 52ddbaeca2dccf53ba2d6dec5676ca7bc3b2403ef8b37f7da78b7654bb3e10f0
   url: https://files.pythonhosted.org/packages/c3/73/f37f428748c4f10a7991ac5bff00f113a34bcc0d0a78957d6e1cdc29a94e/imageio-2.9.0.tar.gz
-  patches:
-  - patches/setitup.patch
 requirements:
   run:
   - numpy
diff --git a/packages/imageio/patches/setitup.patch b/packages/imageio/patches/setitup.patch
deleted file mode 100644
index a086150da52..00000000000
--- a/packages/imageio/patches/setitup.patch
+++ /dev/null
@@ -1,35 +0,0 @@
-diff --git a/imageio/core/findlib.py b/imageio/core/findlib.py
---- a/imageio/core/findlib.py
-+++ b/imageio/core/findlib.py
-@@ -7,7 +7,6 @@
- 
- import os
- import sys
--import ctypes
- 
- 
- LOCALDIR = os.path.abspath(os.path.dirname(__file__))
-@@ -95,6 +94,7 @@ def load_lib(exact_lib_names, lib_names, lib_dirs=None):
- 
-     Returns ``(ctypes_library, library_path)``
-     """
-+    import ctypes
- 
-     # Checks
-     assert isinstance(exact_lib_names, list)
-
-diff --git a/imageio/plugins/__init__.py b/imageio/plugins/__init__.py
-index 7e26683..971f83e 100644
---- a/imageio/plugins/__init__.py
-+++ b/imageio/plugins/__init__.py
-@@ -84,8 +84,8 @@ from . import tifffile
- from . import pillow
- from . import grab
- 
--from . import freeimage
--from . import freeimagemulti
-+# from . import freeimage
-+# from . import freeimagemulti
- 
- from . import ffmpeg
- 
diff --git a/packages/joblib/meta.yaml b/packages/joblib/meta.yaml
index 9d1bc1f66a3..e1c45543a77 100644
--- a/packages/joblib/meta.yaml
+++ b/packages/joblib/meta.yaml
@@ -12,7 +12,6 @@ source:
 
   patches:
     - patches/use-setuptools.patch
-    - patches/ctypes-import.patch
 
 test:
   imports:
diff --git a/packages/joblib/patches/ctypes-import.patch b/packages/joblib/patches/ctypes-import.patch
deleted file mode 100644
index 12442d3ce6b..00000000000
--- a/packages/joblib/patches/ctypes-import.patch
+++ /dev/null
@@ -1,21 +0,0 @@
-diff --git a/joblib/backports.py b/joblib/backports.py
-index 7dd3df1..a49ef78 100644
---- a/joblib/backports.py
-+++ b/joblib/backports.py
-@@ -3,7 +3,6 @@ Backports of fixes for joblib dependencies
- """
- import os
- import time
--import ctypes
- import sys
- 
- from distutils.version import LooseVersion
-@@ -34,6 +33,8 @@ except ImportError:
- 
- if os.name == 'nt':
-     error_access_denied = 5
-+    import ctypes
-+
-     try:
-         from os import replace
-     except ImportError:
diff --git a/packages/numpy/meta.yaml b/packages/numpy/meta.yaml
index d3562c53f54..e9e5912604f 100644
--- a/packages/numpy/meta.yaml
+++ b/packages/numpy/meta.yaml
@@ -20,7 +20,6 @@ source:
     - patches/make-int-return-values.patch
     - patches/fix-ieee754.patch
     - patches/rm-duplicate-symbols-link.patch
-    - patches/delay-ctypes-import.patch
 
 build:
   skip_host: False
diff --git a/packages/numpy/patches/delay-ctypes-import.patch b/packages/numpy/patches/delay-ctypes-import.patch
deleted file mode 100644
index ee994a1c927..00000000000
--- a/packages/numpy/patches/delay-ctypes-import.patch
+++ /dev/null
@@ -1,86 +0,0 @@
-Delay ctypes imports
-
-Included in numpy 1.20.0 (https://github.com/numpy/numpy/pull/16387)
-
-diff --git a/numpy/core/_dtype_ctypes.py b/numpy/core/_dtype_ctypes.py
-index 708241289..6d7cbb244 100644
---- a/numpy/core/_dtype_ctypes.py
-+++ b/numpy/core/_dtype_ctypes.py
-@@ -22,9 +22,10 @@ Unfortunately, this fails because:
- * PEP3118 cannot represent unions, but both numpy and ctypes can
- * ctypes cannot handle big-endian structs with PEP3118 (bpo-32780)
- """
--import _ctypes
--import ctypes
- 
-+# We delay-import ctypes for distributions that do not include it.
-+# While this module is not used unless the user passes in ctypes
-+# members, it is eagerly imported from numpy/core/__init__.py.
- import numpy as np
- 
- 
-@@ -39,6 +40,7 @@ def _from_ctypes_structure(t):
-                 "ctypes bitfields have no dtype equivalent")
- 
-     if hasattr(t, "_pack_"):
-+        import ctypes
-         formats = []
-         offsets = []
-         names = []
-@@ -79,6 +81,7 @@ def _from_ctypes_scalar(t):
- 
- 
- def _from_ctypes_union(t):
-+    import ctypes
-     formats = []
-     offsets = []
-     names = []
-@@ -98,6 +101,7 @@ def dtype_from_ctypes_type(t):
-     """
-     Construct a dtype object from a ctypes type
-     """
-+    import _ctypes
-     if issubclass(t, _ctypes.Array):
-         return _from_ctypes_array(t)
-     elif issubclass(t, _ctypes._Pointer):
-diff --git a/tools/openblas_support.py b/tools/openblas_support.py
-index 6b2ad0f8c..cbb6a5e43 100644
---- a/tools/openblas_support.py
-+++ b/tools/openblas_support.py
-@@ -207,12 +207,12 @@ def make_init(dirname):
-             and is created as part of the scripts that build the wheel.
-             '''
-             import os
--            from ctypes import WinDLL
-             import glob
-             if os.name == 'nt':
-                 # convention for storing / loading the DLL from
-                 # numpy/.libs/, if present
-                 try:
-+                    from ctypes import WinDLL
-                     basedir = os.path.dirname(__file__)
-                 except:
-                     pass
-@@ -221,16 +221,16 @@ def make_init(dirname):
-                     DLL_filenames = []
-                     if os.path.isdir(libs_dir):
-                         for filename in glob.glob(os.path.join(libs_dir,
--                                                             '*openblas*dll')):
-+                                                               '*openblas*dll')):
-                             # NOTE: would it change behavior to load ALL
-                             # DLLs at this path vs. the name restriction?
-                             WinDLL(os.path.abspath(filename))
-                             DLL_filenames.append(filename)
--                if len(DLL_filenames) > 1:
--                    import warnings
--                    warnings.warn("loaded more than 1 DLL from .libs:\\n%s" %
--                              "\\n".join(DLL_filenames),
--                              stacklevel=1)
-+                    if len(DLL_filenames) > 1:
-+                        import warnings
-+                        warnings.warn("loaded more than 1 DLL from .libs:\\n%s" %
-+                                      "\\n".join(DLL_filenames),
-+                                      stacklevel=1)
-     """))
- 
- def test_setup(arches):
diff --git a/packages/setuptools/meta.yaml b/packages/setuptools/meta.yaml
index 3d4e2ca33fd..9490eeea102 100644
--- a/packages/setuptools/meta.yaml
+++ b/packages/setuptools/meta.yaml
@@ -6,9 +6,6 @@ source:
   url: https://files.pythonhosted.org/packages/88/fc/d17731c0cc67a5a8e385e4f47c3b0b186720e198b70f076ccb4676804a8f/setuptools-57.0.0.tar.gz
   sha256: 401cbf33a7bf817d08014d51560fc003b895c4cdc1a5b521ad2969e928a07535
 
-  patches:
-    - patches/remove-ctypes.patch
-
 requirements:
   run:
     - distutils
diff --git a/packages/setuptools/patches/remove-ctypes.patch b/packages/setuptools/patches/remove-ctypes.patch
deleted file mode 100644
index 5e9f736f7cb..00000000000
--- a/packages/setuptools/patches/remove-ctypes.patch
+++ /dev/null
@@ -1,22 +0,0 @@
-From 7e50329062af2b51d0e551c6c80fc5b457263639 Mon Sep 17 00:00:00 2001
-From: Hood <hood@mit.edu>
-Date: Tue, 15 Jun 2021 09:06:01 -0700
-Subject: [PATCH] Remove ctypes import
-
----
- setuptools/windows_support.py | 1 -
- 1 file changed, 1 deletion(-)
-
-diff --git a/setuptools/windows_support.py b/setuptools/windows_support.py
-index cb977cf..0324739 100644
---- a/setuptools/windows_support.py
-+++ b/setuptools/windows_support.py
-@@ -1,5 +1,4 @@
- import platform
--import ctypes
- 
- 
- def windows_only(func):
--- 
-2.17.1
-
diff --git a/run_docker b/run_docker
index 0cd457ede32..5d16eacf0df 100755
--- a/run_docker
+++ b/run_docker
@@ -1,7 +1,7 @@
 #!/usr/bin/env bash
 
 PYODIDE_IMAGE_REPO="pyodide"
-PYODIDE_IMAGE_TAG="17"
+PYODIDE_IMAGE_TAG="18"
 PYODIDE_PREBUILT_IMAGE_TAG="0.17.0"
 DEFAULT_PYODIDE_DOCKER_IMAGE="${PYODIDE_IMAGE_REPO}/pyodide-env:${PYODIDE_IMAGE_TAG}"
 DEFAULT_PYODIDE_SYSTEM_PORT="8000"
diff --git a/src/core/main.c b/src/core/main.c
index f39964cf529..2902beef42d 100644
--- a/src/core/main.c
+++ b/src/core/main.c
@@ -132,6 +132,7 @@ main(int argc, char** argv)
     // For some reason emscripten doesn't make UTF8ToString available on Module
     // by default...
     Module.UTF8ToString = UTF8ToString;
+    Module.wasmTable = wasmTable;
   });
 
   TRY_INIT_WITH_CORE_MODULE(error_handling);