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Fig3

Fig.3: Pan-Cancer and cancer-specific regulons.


Directory structure

  • Run_SCENIC -- inferring regulons using SCENIC

  • Post_SCENIC -- scripts for updating regulons based on frequency across iterations; and for identifying differential regulons: each cancer vs others (tumor cells only), and each tumor vs CNC.

  • Diff_TFs_ATAC_based -- identifying differential TFs: each cancer vs others (tumor cells only), and each tumor vs CNC.

  • ENCODE_validation -- validation of regulons' targets using ChIP-seq data (ENCODE).