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The functions of herpesvirus-encoded microRNAs

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Abstract

Bioinformatic and direct cloning approaches have led to the identification of over 100 novel miRNAs expressed in DNA viruses, although the function of the majority of these small regulatory RNA molecules is unclear. Recently, a number of reports have now identified potential targets of viral miRNAs, including cellular and viral genes as well as an ortholog of an important immuno-regulatory cellular miRNA. In this review, we will cover the identification and characterization of miRNAs expressed in the herpesvirus family and discuss the potential significance of their role in viral infection.

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Authors and Affiliations

  1. Vaccine and Gene Therapy Institute, Oregon Health Sciences University, 505 NW 185th Ave, Portland, OR, 97006, USA

    Finn Grey, Lauren Hook & Jay Nelson

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  1. Finn Grey
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  2. Lauren Hook
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Correspondence to Finn Grey.

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Grey, F., Hook, L. & Nelson, J. The functions of herpesvirus-encoded microRNAs. Med Microbiol Immunol 197, 261–267 (2008). https://doi.org/10.1007/s00430-007-0070-1

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