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Planta Med 1998; 64(6): 525-529
DOI: 10.1055/s-2006-957507
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Inhibitory Effects of Angelica pubescens f. biserrata on 5-Lipoxygenase and Cyclooxygenase

J. H. Liu, S. Zschocke, E. Reininger, R. Bauer
  • Institute of Pharmaceutical Biology, University Düsseldorf, Düsseldorf, Germany
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Publication History

1997

1998

Publication Date:
01 February 2007 (online)

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Abstract

Linoleic acid, osthol, osthenol and two polyacetylenes, falcarindiol and 11(S),16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1-yl acetate were found to be the most active compounds responsible for the inhibitory activity of the di-chloromethane extract of the roots of Angelica pubescens f. biserrata on 5-lipoxygenase (5-LO) and cyclooxygenase (COX-1) in vitro. They showed prominent inhibitory effect on 5-LO with IC50 values of 27.9 µM, 36.2 µM, 43.1 µM, 9.4 µM and 24.0 µM, respectively. Linoleic acid, osthenol, falcarindiol and 11 (S), 16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1-yl acetate exhibited inhibitory activity on COX-1 with IC50 values of 13.3 µM, 64.3µM, 66.0 µM and 73.3 µM.

Key words

Angelica pubescens f. biserrata - Umbelliferae - 5-lipoxygenase - cyclooxygenase - linoleic acid - osthol - osthenol - falcarindiol - 11(S)16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1-yl acetate