Abstract
The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−5 − 5 × 10−7 in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 × 10−8) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-α–induced protein 3 (TNFAIP3).
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Acknowledgements
Funding for this study was provided by the Arthritis Research Campaign (arc). We thank the Wellcome Trust for funding the WTCCC. We would also like to acknowledge the National Health Service (NHS) Research and Development Support Fund for Guy's and St Thomas' and Lewisham NHS Trusts. We acknowledge use of DNA from the British 1958 Birth Cohort collection, funded by the Medical Research Council grant G0000934 and the Wellcome Trust grant 068545/Z/02. IT support was provided by M. Lay, and technical support was provided by P. Gilbert, B. Lad and S.G. Martin. Nursing support was provided by J. Grumley, J. Shotton and C. Farrar.
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W.T., A.B., X.K., S.E. and J.W. participated in the conception, design and coordination of the study, data analysis and writing of the manuscript. D.S., S.H., I.N.B., A.G.W., I.M., A.M., P.E., YEAR Consortium, A.C., S.S., L.H., D.M.R., P.W., P.H. and D.S. recruited study subjects and extracted phenotype data. S.E., A.H. and J.B. performed the genotyping. X.K. undertook the statistical analysis. R.D. contributed to preparation of the manuscript. WTCCC provided the initial data for rheumatoid arthritis cases and controls. Members of the WTCCC and YEAR consortium are listed in the Supplementary Note.
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For full lists of members of these consortia, see Supplementary Note
For full lists of members of these consortia, see Supplementary Note
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Supplementary Tables 1–5, Supplementary Figure 1, Supplementary Methods, Supplementary Note (PDF 154 kb)
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Thomson, W., Barton, A., Ke, X. et al. Rheumatoid arthritis association at 6q23. Nat Genet 39, 1431–1433 (2007). https://doi.org/10.1038/ng.2007.32
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DOI: https://doi.org/10.1038/ng.2007.32
