Skip to main content

Advertisement

Springer Nature Link
Log in

Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review

  • Review
  • Published:
Familial Cancer Aims and scope Submit manuscript

Abstract

Lifestyle factors related to energy balance, such as excess body weight, poor diet, and physical inactivity, are associated with risk of sporadic endometrial cancer (EC) and colorectal cancer (CRC). There are limited data on energy balance-related lifestyle factors and EC or CRC risk among individuals with lynch syndrome, who are at extraordinarily higher risk of developing EC or CRC. We conducted a systematic review of evidence related to weight status, weight change, dietary habits, and physical activity on EC and CRC risk among individuals with lynch syndrome. Findings are reported narratively. We searched Medline, EMBASE, CENTRAL, PubMed, and clinicaltrials.gov up to June 14th, 2018. In total, 1060 studies were identified and 16 were included. Three studies were related to EC and 13 to CRC. Overall, evidence suggests that weight status/weight change may not be associated with EC risk and multivitamin and folic-acid supplementation may be associated with decreased EC risk. Early-adulthood overweight/obese weight-status and adulthood weight-gain may be associated with increased CRC risk, whereas multivitamin supplementation, tea and high fruit intake, and physical activity may be associated with decreased CRC risk. Current evidence proposes that recommendations related to weight, some dietary habits, and physical activity recommended for the general public are also relevant to individuals with lynch syndrome. More research is needed, specifically prospective cohorts and randomized controlled trials, to determine if tailored recommendations are needed among individuals with lynch syndrome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Canada)

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Spira A, Yurgelun M, Alexandrov L et al (2017) Precancer atlas to drive precision prevention trials. Cancer Res 77(7):1510–1541. https://doi.org/10.1158/0008-5472.CAN-16-2346

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Aaltonen M, Staff S, Mecklin J, Pylvänäinen K, Mäenpää J (2017) Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: a retrospective case-case study. Mol Clin Oncol 6(5):758–764. https://doi.org/10.3892/mco.2017.1211

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Aarnio M, Mecklin J, Aaltonen L, Nyström-Lahti M, Järvinen H (1995) Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer 64(6):430–433

    Article  CAS  PubMed  Google Scholar 

  4. Lynch H, Lynch P, Lanspa S et al (2009) Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications. Clin Genet 76(1):1–18. https://doi.org/10.1111/j.1399-0004.2009.01230.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Møller P, Seppälä T, Bernstein I et al (2017) Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database. Gut. https://doi.org/10.1136/gutjnl-2017-314057

    Article  PubMed  Google Scholar 

  6. Møller P, Seppälä T, Bernstein I et al (2017) Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database. Gut 66(3):464–472. https://doi.org/10.1136/gutjnl-2015-309675

    Article  PubMed  Google Scholar 

  7. Diergaarde B, Braam H, Vasen H et al (2007) Environmental factors and colorectal tumor risk in individuals with hereditary nonpolyposis colorectal cancer. Clin Gastroenterol Hepatol 5(6):736–742

    Article  PubMed  Google Scholar 

  8. World Cancer Research Fund/American Institute for Cancer Research. Continuous update project expert report 2018. Diet, nutrition, physical activity and colorectal cancer. https://dietandcancerreport.org

  9. World Cancer Research Fund/American Institute for Cancer Research. Continuous update project expert report 2018. Diet, nutrition, physical activity and endometrial cancer. https://dietandcancerreport.org

  10. Filomeno M, Bosetti C, Bidoli E et al (2015) Mediterranean diet and risk of endometrial cancer: a pooled analysis of three Italian case-control studies. Br J Cancer 112(11):1816–1821. https://doi.org/10.1038/bjc.2015.153

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Schwingshackl L, Hoffmann G (2016) Does a mediterranean-type diet reduce cancer risk? Curr Nutr Rep 5:9–17. https://doi.org/10.1007/s13668-015-0141-7

    Article  CAS  PubMed  Google Scholar 

  12. van Duijnhoven F, Botma A, Winkels R et al (2013) Do lifestyle factors influence colorectal cancer risk in Lynch syndrome? Fam Cancer 12(2):285–293. https://doi.org/10.1007/s10689-013-9645-8

    Article  PubMed  Google Scholar 

  13. Liberati A, Altman D, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62(10):e1-34

    Article  PubMed  Google Scholar 

  14. Boyle T, Keegel T, Bull F, Heyworth J, Fritschi LP (2012) Activity and risks of proximal and distal colon cancers: a systematic review and meta-analysis. J Natl Cancer Inst 104(20):1548–1561. https://doi.org/10.1093/jnci/djs354

    Article  PubMed  Google Scholar 

  15. Singh S, Edakkanambeth Varayil J, Devanna S, Murad M, Iyer P (2014) Physical activity is associated with reduced risk of gastric cancer: a systematic review and meta-analysis. Cancer Prev Res (Phila) 7(1):12–22.

    Article  Google Scholar 

  16. Maenpaa J, Aaltonen M, Mecklin J, Staff S (2016) Evaluation of factors modifying endometrial cancer risk among women with Lynch syndrome: a cohort study. J Clin Oncol 34:e17113

    Article  Google Scholar 

  17. Win A, Chau R, Dashti S et al (2014) Lifestyle modifiers of risk of endometrial cancer for women with germline mutations in DNA mismatch repair genes. Int J Gynecol Cancer 24(9 suppl 4):1577–1578. https://doi.org/10.1097/01.IGC.0000457075.08973.89

    Article  Google Scholar 

  18. Win A, Dowty J, Antill Y et al (2011) Body mass index in early adulthood and endometrial cancer risk for mismatch repair gene mutation carriers. Obstet Gynecol 117(4):899–905. https://doi.org/10.1097/AOG.0b013e3182110ea3

    Article  PubMed  PubMed Central  Google Scholar 

  19. Botma A, Nagengast F, Braem M et al (2010) Body mass index increases risk of colorectal adenomas in men with Lynch syndrome: the GEOLynch cohort study. J Clin Oncol 28(28):4346–4353. https://doi.org/10.1200/JCO.2010.28.0453

    Article  PubMed  Google Scholar 

  20. Botma A, Vasen H, van Duijnhoven F et al (2013) Dietary patterns and colorectal adenomas in Lynch syndrome: the GEOLynch cohort study. Cancer 119(3):512–521. https://doi.org/10.1002/cncr.27726

    Article  PubMed  Google Scholar 

  21. Campbell P, Cotterchio M, Dicks E et al (2007) Excess body weight and colorectal cancer risk in Canada: associations in subgroups of clinically defined familial risk of cancer. Cancer Epidemiol Biomark Prev 16(9):1735–1744. https://doi.org/10.1158/1055-9965.EPI-06-1059

    Article  Google Scholar 

  22. Chau R, Dashti S, Ait Ouakrim D et al (2016) Multivitamin, calcium and folic acid supplements and the risk of colorectal cancer in Lynch syndrome. Int J Epidemiol 45(3):940–953. https://doi.org/10.1093/ije/dyw036

    Article  PubMed  PubMed Central  Google Scholar 

  23. Dashti S, Win W, Hardikar S et al (2018) Physical activity and the risk of colorectal cancer in Lynch Syndrome. Int J Cancer. https://doi.org/10.1002/ijc.31611 (Epub ahead of print)

    Article  PubMed  PubMed Central  Google Scholar 

  24. Heine-Broring R, Winkels R, Botma A et al (2013) Dietary supplement use and colorectal adenoma risk in individuals with lynch syndrome: the GEOLynch Cohort Study. PLoS ONE 8(6):e66819. https://doi.org/10.1371/journal.pone.0066819

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Kamiza A, Hsieh L, Tang R et al (2015) Risk Factors Associated with Colorectal Cancer in a Subset of Patients with Mutations in MLH1 and MSH2 in Taiwan Fulfilling the Amsterdam II Criteria for Lynch Syndrome. PLoS ONE 10(6):e0130018. https://doi.org/10.1371/journal.pone.0130018

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Winkels R, Botma A, Nagengast F, Vasen H, Kampman E (2011) Smoking and alcohol consumption and colorectal adenoma risk in Lynch syndrome: the GEOLynch cohort study. Fam Cancer 10:S8. https://doi.org/10.1007/s10689-011-9424-3

    Article  Google Scholar 

  27. Win A, Dowty J, English D et al (2011) Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes. Br J Cancer 105(1):162–169. https://doi.org/10.1038/bjc.2011.172

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Dashti SG, Buchanan DD, Jayasekara H et al (2017) Alcohol consumption and the risk of colorectal cancer for mismatch repair gene mutation carriers. Cancer Epidemiol Biomark Prev 26(3):366–375. https://doi.org/10.1158/1055-9965.Epi-16-0496

    Article  CAS  Google Scholar 

  29. Miguchi M, Hinoi T, Tanakaya K et al (2018) Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum. Surg Today (Epub ahead of print). https://doi.org/10.1007/s00595-018-1654-7

    Article  PubMed  Google Scholar 

  30. Watson P, Ashwathnarayan R, Lynch HT, Roy HK (2004) Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome). Arch Intern Med 164:2429–2431

    Article  PubMed  Google Scholar 

  31. Winkels RM, Botma A, Van Duijnhoven FJ et al (2012) Smoking increases the risk for colorectal adenomas in patients with Lynch syndrome. Gastroenterology 142(2):241–247. https://doi.org/10.1053/j.gastro.2011.10.033

    Article  PubMed  Google Scholar 

  32. World Cancer Research Fund International/American Institute for Cancer Research (2013) Continuous update project report: food, nutrition, physical activity and the prevention of endometrial cancer. wcrf.org/sites/default/files/Endometrial-Cancer-2013-Report.pdf

  33. Yoo H, Joo J, Seo S et al (2012) Correlation between body mass index and prevalence of hereditary nonpolyposis colorectal cancer in Korean patients with endometrial cancer. Int J Gynecol Cancer 22(2):267–272. https://doi.org/10.1097/IGC.0b013e31823b3650

    Article  PubMed  Google Scholar 

  34. Jain M, Rohan T, Howe G, Miller (2000) A A cohort study of nutritional factors and endometrial cancer. Eur J Epidemiol 16(10):899–905

    Article  CAS  PubMed  Google Scholar 

  35. Neuhouser M, Wassertheil-Smoller S, Thomson C et al (2009) Multivitamin use and risk of cancer and cardiovascular disease in the Women’s Health Initiative cohorts. Arch Intern Med 169(3):294–304. https://doi.org/10.1001/archinternmed.2008.540

    Article  PubMed  Google Scholar 

  36. Research WCRFIAIfC Continuous update project report: the association between food, nutrition, physical activity and the risk of endometrial cancer (2012)

  37. Du L, Wang Y, Zhang H, Zhang H, Gao Y (2016) Folate intake and the risk of endometrial cancer: a meta-analysis. Oncotarget 7(51):85176–85184

    Article  PubMed  PubMed Central  Google Scholar 

  38. McCann S, Freudenheim J, Marshall J et al (2000) Diet in the epidemiology of endometrial cancer in western New York (United States). Cancer Causes Control 11(10):965–974

    Article  CAS  PubMed  Google Scholar 

  39. Potischman N, Swanson C, Brinton L et al (1993) Dietary associations in a case-control study of endometrial cancer. Cancer Causes Control 4(3):239–250

    CAS  PubMed  Google Scholar 

  40. Uccella S, Mariani A, Wang A et al (2011) Dietary and supplemental intake of one-carbon nutrients and the risk of type I and type II endometrial cancer: a prospective cohort study. Ann Oncol 22(9):2129–2136. https://doi.org/10.1093/annonc/mdq724

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. World Cancer Research Fund International/American Institute for Cancer Research (2017) Continuous update project report: diet, nutrition, physical activity and colorectal cancer. https://wcrf.org/colorectal-cancer-2017

  42. Matsuo K, Mizoue T, Tanaka K et al (2012) Association between body mass index and the colorectal cancer risk in Japan: pooled analysis of population-based cohort studies in Japan. Ann Oncol 23(2):479–490. https://doi.org/10.1093/annonc/mdr143

    Article  CAS  PubMed  Google Scholar 

  43. Day D, Morson B (1978) The adenoma-carcinoma sequence. Major Probl Pathol 10:58–71

    CAS  PubMed  Google Scholar 

  44. Hill M, Morson B, Bussey H (1978) Aetiology of adenoma–carcinoma sequence in large bowel. Lancet 1(8058):245–247

    Article  CAS  PubMed  Google Scholar 

  45. Okabayashi K, Ashrafian H, Hasegawa H et al (2012) Body mass index category as a risk factor for colorectal adenomas: a systematic review and meta-analysis. Am J Gastroenterol 107(8):1175–1185. https://doi.org/10.1038/ajg.2012.180

    Article  PubMed  Google Scholar 

  46. Aune D, Chan D, Vieira A et al (2013) Red and processed meat intake and risk of colorectal adenomas: a systematic review and meta-analysis of epidemiological studies. Cancer Causes Control 24(4):611–627. https://doi.org/10.1007/s10552-012-0139-z

    Article  PubMed  Google Scholar 

  47. Xu X, Yu E, Gao X et al (2013) Red and processed meat intake and risk of colorectal adenomas: a meta-analysis of observational studies. Int J Cancer 132(2):437–448. https://doi.org/10.1002/ijc.27625

    Article  CAS  PubMed  Google Scholar 

  48. Cottet V, Bonithon-Kopp C, Kronborg O et al (2005) Dietary patterns and the risk of colorectal adenoma recurrence in a European intervention trial. Eur J Cancer Prev 14(1):21–29

    Article  CAS  PubMed  Google Scholar 

  49. Lee I, Shiroma E, Lobelo F et al (2012) Effect of physical inactivity on major non-communicable disease worldwide: an analysis of burden of disease and life expectancy. Lancet 380:219–229

    Article  PubMed  PubMed Central  Google Scholar 

  50. Schmid D, Leitzmann M (2014) Television viewing and time spent sedentary in relation to cancer risk: a meta-analysis. J Natl Cancer Inst. https://doi.org/10.1093/jnci/dju098

    Article  PubMed  PubMed Central  Google Scholar 

  51. Giovannucci E, Ascherio A, Rimm E et al (1995) Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 122:327–334

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R25CA057730 (PI: Shine Chang, PhD), by the Center for Energy Balance in Cancer Prevention and Survivorship, Duncan Family Institute for Cancer Prevention and Risk Assessment, and by MRSG-13-145-01 from the American Cancer Society.

Author information

Authors and Affiliations

  1. Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Adriana M. Coletta, Susan K. Peterson, Leticia A. Gatus, Susan M. Schembre & Karen Basen-Engquist

  2. Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, UT, USA

    Adriana M. Coletta

  3. Department of Health, Kinesiology, and Recreation, The University of Utah, Salt Lake City, UT, USA

    Adriana M. Coletta

  4. Research Medical Library, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Kate J. Krause

  5. Department of Family and Community Medicine, College of Medicine-Tucson, University of Arizona, Tucson, AZ, 85724, USA

    Susan M. Schembre

  6. Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Susan C. Gilchrist & Eduardo Vilar

  7. Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Mala Pande & Patrick M. Lynch

  8. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Y. Nancy You & Miguel A. Rodriguez-Bigas

  9. Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Larkin L. Strong

  10. Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Karen H. Lu

  11. The University of Texas MD Anderson Cancer Center, Unit 1330, P.O. Box 301439, Houston, TX, 77230-1439, USA

    Karen Basen-Engquist

Authors
  1. Adriana M. Coletta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Susan K. Peterson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Leticia A. Gatus
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kate J. Krause
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Susan M. Schembre
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Susan C. Gilchrist
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mala Pande
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Eduardo Vilar
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Y. Nancy You
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Miguel A. Rodriguez-Bigas
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Larkin L. Strong
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Patrick M. Lynch
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Karen H. Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Karen Basen-Engquist
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Karen Basen-Engquist.

Ethics declarations

Conflict of interest

The authors have no conflicts of interest to disclose.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOCX 13 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Coletta, A.M., Peterson, S.K., Gatus, L.A. et al. Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review. Familial Cancer 18, 399–420 (2019). https://doi.org/10.1007/s10689-019-00135-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10689-019-00135-7

Keywords

Search

Navigation