Abstract
The present study investigated the impact of a single oral ingestion of ginger on thermoregulatory function and fat oxidation in humans. Morning and afternoon oral intake of 1.0 g dried ginger root powder did not alter rectal temperature, skin blood flow, O2 consumption, CO2 production, and thermal sensation and comfort, or induce sweating at an ambient temperature of 28 °C. Ginger ingestion had no effect on threshold temperatures for skin blood flow or thermal sweating. Serum levels of free fatty acids were significantly elevated at 120 min after ginger ingestion in both the morning and afternoon. Morning ginger intake significantly reduced respiratory exchange ratios and elevated fat oxidation by 13.5 % at 120 min after ingestion. This was not the case in the afternoon. These results suggest that the effect of a single oral ginger administration on the peripheral and central thermoregulatory function is miniscule, but does facilitate fat utilization although the timing of the administration may be relevant.
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Alizadeh-Navaei R, Roozbeh F, Saravi M, Pouramir M, Jalali F, Moghadamnia AA (2008) Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi Med J 29:1280–1284
Bailley SM, Udoh US, Young ME (2014) Circadian regulation of metabolism. J Endocrinol R75–R96
Beattie JH, Nicol F, Gordon MJ, Reid MD, Cantlay L, Horgan GW, Kwun IS, Ahn JY, Ha TY (2011) Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: a proteomic and biomarker network analysis. Mol Nutr Food Res 55:S203–S213
Bode AM, Ma WY, Surh YJ, Dong Z (2001) Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Cancer Res 61:850–853
Brown AC, Shah C, Liu J, Pham JT, Zhang JG, Jadus MR (2009) Ginger’s (Zingiber officinale Roscoe) inhibition of rat colonic adenocarcinoma cells proliferation and angiogenesis in vitro. Phytother Res 23:640–645
Cabanac M, Brinnel H (1987) The pathology of human temperature regulation: thermiatrics. Experientia 43:19–27
Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, Leeprakobboon K, Leelasettagool C (2006) The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. Am J Obstet Gynecol 194:95–99
Chatonnet J, Cabanac M (1965) The perception of thermal comfort. Int J Biometeorol 9:183–193
Chittumma P, Kaewkiattikun K, Wiriyasiriwach B (2007) Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 90:15–20
Ernst E, Pittler MH (2000) Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Br J Anaesth 84:367–371
Frayn KN (1983) Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol Respir Environ Exerc Physiol 55:628–634
Gonlachanvit S, Chen YH, Hasler WL, Sun WM, Owyang C (2003) Ginger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: possible role of endogenous prostaglandins. J Pharmacol Exp Ther 307:1098–1103
Grivel F, Candas V (1991) Ambient temperatures preferred by young European males and females at rest. Ergonomics 34:365–378
Grzanna R, Lindmark L, Frondoza CG (2005) Ginger—an herbal medicinal product with broad anti-inflammatory actions. J Med Food 8:125–132
Hara T, Maruyama M, Hashimoto T, Matsuzaki K, Hashimoto M, Katakura M, Shido O (2007) Effects of short-term food deprivation on sweating and shivering thresholds. Shimane J Med Sci 24:37–42
Hashimoto M, Shinozuka K, Gamoh S, Tanabe Y, Hossain MS, Kwon YM, Hata N, Misawa Y, Kunitomo M, Masumura S (1999) The hypotensive effect of docosahexaenoic acid is associated with the enhanced release of ATP from the caudal artery of aged rats. J Nutr 129:70–76
Hirata K, Nagasaka T, Hirai A, Hirashita M, Takahata T, Nunomura T (1986) Effects of human menstrual cycle on thermoregulatory vasodilation during exercise. Eur J Appl Physiol Occup Physiol 54:559–565
Iwasaki Y, Morita A, Iwasawa T, Kobata K, Sekiwa Y, Morimitsu Y, Kubota K, Watanabe T (2006) A nonpungent component of steamed ginger—[10]-shogaol—increases adrenaline secretion via the activation of TRPV1. Nutr Neurosci 9:169–178
Izumida Y, Yahagi N, Takeuchi Y, Nishi M, Shikama A, Takarada A, Masuda Y, Kubota M, Matsuzaka T, Nakagawa Y, Iizuka Y, Itaka K, Kataoka K, Shioda S, Niijima A, Yamada T, Katagiri H, Nagai R, Yamada N, Kadowaki T, Shimano H (2013) Glycogen shortage during fasting triggers liver–brain–adipose neurocircuitry to facilitate fat utilization. Nat Commun 4:2316
Kim SO, Kundu JK, Shin YK, Park JH, Cho MH, Kim TY, Surh YJ (2005) [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene 24:2558–2567
Lien HC, Sun WM, Chen YH, Kim H, Hasler W, Owyang C (2003) Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection. Am J Physiol Gastrointest Liver Physiol 284:G481–G489
Liu CT, Raghu R, Lin SH, Wang SY, Kuo CH, Tseng YJ, Sheen LY (2013) Metabolomics of ginger essential oil against alcoholic fatty liver in mice. J Agric Food Chem 61:11231–11240
Nagai K, Niijima A, Horii Y, Shen J, Tanida M (2014) Olfactory stimulatory with grapefruit and lavender oils change autonomic nerve activity and physiological function. Auton Neurosci 185:29–35
Nwozo SO, Osunmadewa DA, Oyinloye BE (2014) Anti-fatty liver effects of oils from Zingiber officinale and Curcuma longa on ethanol-induced fatty liver in rats. J Integr Med 12:59–65
Ogawa T, Sugenoya J (1993) Pulsatile sweating and sympathetic sudomotor activity. Jpn J Physiol 43:275–289
Ogawa T, Satoh T, Takagi K (1967) Sweating during night sleep. Jpn J Physiol 17:135–148
Ohta H, Maruyama M, Tanabe Y, Hara T, Nishino Y, Tsujino Y, Morita E, Kobayashi S, Shido O (2008a) Effects of redecoration of a hospital isolation room with natural materials on stress levels of denizens in cold season. Int J Biometeorol 52:331–340
Ohta H, Tanabe Y, Nishino Y, Maruyama M, Katakura M, Matsuzaki K, Li G, Kobayashi S, Shido O (2008b) Effects of summertime redecoration of a hospital isolation room on occupiers’ physiological functions. J J Biometeorol 45:73–84
Peek CB, Affinati AH, Ramsey KM, Kuo HY, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, Chandel NS, Denu JM, Mrksich M, Bass J (2013) Science 342:1243417
Pertz HH, Lehmann J, Roth-Ehrang R, Elz S (2011) Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors. Planta Med 77:973–978
Prakash UN, Srinivasan K (2012) Fat digestion and absorption in spice-pretreated rats. J Sci Food Agric 92:503–510
Quinla JD, Hill DA (2003) Nausea and vomiting of pregnancy. Am Fam Physician 68:121–128
Rabellato P, Islam MS (2014) [6]-Shogaol induces Ca(2)(+) signals by activating the TRPV1 channels in the rat insulinoma INS-1E cells. JOP 15:33–37
Romanovsky AA (2004) Do fever and anapyrexia exist? Analysis of set point-based definitions. Am J Physiol Regul Integr Comp Physiol 287:R992–R995
Romanovsky AA, Simons CT, Kulchitsky VA, Sugimoto N, Szekely M (1998) Vagus nerve in fever. Recent developments. Ann N Y Acad Sci 856:298–299
Romanovsky AA, Almeida MC, Aronoff DM, Ivanov AI, Konsman JP, Steiner AA (2005) Fever and hypothermia in systemic inflammation: recent discoveries and revisions. Front Biosci 10:2193–2216
Roth J, De Souza GE (2001) Fever induction pathways: evidence from responses to systemic or local cytokine formation. Braz J Med Biol Res 34:301–314
Shao X, Lv L, Parks T, Wu H, Ho CT, Sang S (2010) Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection. J Agric Food Chem 58:12608–12614
Shen J, Niijima A, Tadida M, Horii K, Nagai K (2005) Olfactory stimulation with scent of grapefruit oil affects autonomic nerves, lipolysis and appetite in rats. Neurosci Lett 380:289–294
Shido O, Sugimoto N (2011) Possible human endogenous cryogens. Curr Protein Pept Sci 12:288–292
Shido O, Sugimoto N, Tanabe M, Sakurada S (1999) Core temperature and sweating onset in humans acclimated to heat given at a fixed daily time. Am J Physiol 276:R1095–R1101
Shido O, Sakurada S, Sugimoto N, Hiratsuka Y, Takuwa Y (2001) Ambient temperatures preferred by humans acclimated to heat given at a fixed daily time. Physiol Behav 72:387–392
Someya A, Horie S, Yamamoto H, Murayama T (2003) Modifications of capsaicin-sensitive neurons in isolated guinea pig ileum by [6]-gingerol and lafutidine. J Pharmacol Sci 92:359–366
Suekawa M, Ishige A, Yuasa K, Sudo K, Aburada M, Hosoya E (1984) Pharmacological studies on ginger. I. Pharmacological actions of pungent constituents, (6)-gingerol and (6)-shogaol. J Pharmacobiodyn 7:836–848
Suekawa M, Aburada M, Hosoya E (1986a) Pharmacological studies on ginger. III. Effect of the spinal destruction on (6)-shogaol-induced pressor response in rats. J Pharmacobiodyn 9:853–860
Suekawa M, Aburada M, Hosoya E (1986b) Pharmacological studies on ginger. II. Pressor action of (6)-shogaol in anesthetized rats, or hindquarters, tail and mesenteric vascular beds of rats. J Pharmacobiodyn 9:842–852
Tao Y, Li W, Liang W, Van Breemen RB (2009) Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography–tandem mass spectrometry. J Agric Food Chem 57:10014–10021
Tornio A, Filppula AM, Kailari O, Neuvonen M, Nyrönen TH, Tapaninen T, Neuvonen PJ, Niemi M, Backman JT (2014) Glucuronidation converts clopidogrel to a strong time-dependent inhibitor of CYP2C8: a phase II metabolite as a perpetrator of drug–drug interactions. Clin Pharmacol Ther 96:498–507
Tsukita S, Yamada T, Uno K, Takahashi K, Kaneko K, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, Ishihara H, Oka Y, Katagiri H (2012) Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals. Cell Metab 16:825–832
Ueki S, Miyoshi M, Shido O, Hasegawa J, Watanabe T (2008) Systemic administration of [6]-gingerol, a pungent constituent of ginger, induces hypothermia in rats via an inhibitory effect on metabolic rate. Eur J Pharmacol 584:87–92
Walstab J, Kruger D, Stark T, Hofmann T, Demir IE, Ceyhan GO, Feistel B, Schemann M, Niesler B (2013) Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. Neurogastroenterol Motil 25:439–447
Yu Y, Zick S, Li X, Zou P, Wright B, Sun D (2011) Examination of the pharmacokinetics of active ingredients of ginger in humans. AAPS J 13:417–426
Zick SM, Djuric Z, Ruffin MT, Litzinger AJ, Normolle DP, Alrawi S, Feng MR, Brenner DE (2008) Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev 17:1930–1936
Acknowledgments
The study was partly supported by Grant-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Sciences and Technology of Japan (20590231). The authors cordially thank Sunsho Pharmaceutical Co., Ltd. for manufacturing and providing ginger and placebo capsules used in this study.
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The authors declare that they have no conflict of interest.
Author’s contribution
Study conception and design: M.M. and O.S. Acquisition of data: M.M., K.M., and T.H. Analysis and interpretation of data: M.M., K.M., M.K., Y.T., and T.H. Drafting of manuscript: M.M., K.M., M.K., and O.S. Critical revision: M.M. and O.S.
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Kentaro Matsuzaki and Masanori Katakura equally contributed to this work.
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Miyamoto, M., Matsuzaki, K., Katakura, M. et al. Oral intake of encapsulated dried ginger root powder hardly affects human thermoregulatory function, but appears to facilitate fat utilization. Int J Biometeorol 59, 1461–1474 (2015). https://doi.org/10.1007/s00484-015-0957-2
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DOI: https://doi.org/10.1007/s00484-015-0957-2