Abstract
There is overwhelming evidence for an involvement of reactive oxygen species (ROS) in the pathogenesis of diabetes-associated vascular complications. However, neither the exact source of the ROS initiating cascades leading to cell dysfunction in diabetes nor their chemical nature is fully understood. Furthermore, despite our knowledge of the crucial role of ROS in diabetes, little is known about the actual targets and the molecular consequences of the interaction of ROS with cellular signalling pathways.
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Received: 29 August 2001 and in revised form:17 December 2001
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Spitaler, M., Graier, W. Vascular targets of redox signalling in diabetes mellitus. Diabetologia 45, 476–494 (2002). https://doi.org/10.1007/s00125-002-0782-0
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DOI: https://doi.org/10.1007/s00125-002-0782-0