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Activation of the NLRP1B inflammasome by caspase-8
Cleavage of the innate immune receptor NLRP1B by various microbial proteases causes the proteasomal degradation of its N-terminal fragment and the...
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Caspase-8 in inflammatory diseases: a potential therapeutic target
Caspase-8, a renowned cysteine-aspartic protease within its enzyme family, initially garnered attention for its regulatory role in extrinsic...
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TNF-α contributes to sarcopenia through caspase-8/caspase-3/GSDME-mediated pyroptosis
Sarcopenia has become a leading cause of disability and mortality in the elderly. It has been reported that programmed cell death (PCD) is associated...
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Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic networks
Procaspase-8 is a key mediator of death receptor (DR)-mediated pathways. Recently, the role of post-translational modifications (PTMs) of...
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Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors
Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing...
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Inhibition of caspase-8 cascade restrains the osteoclastogenic fate of bone marrow cells
Osteoclasts are multinucleated cells of hematopoietic origin, with a pivotal role in bone development and remodeling. Failure in osteoclast...
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Analyzing Caspase-8-Dependent GSDMD Cleavage in Response to Yersinia Infection
Caspase-8 is best known to drive an immunologically silent form of cell death known as apoptosis. However, emerging studies revealed that upon...
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Dichloroacetate reduces cisplatin-induced apoptosis by inhibiting the JNK/14-3-3/Bax/caspase-9 pathway and suppressing caspase-8 activation via cFLIP in murine tubular cells
Cisplatin-induced injury to renal proximal tubular cells stems from mitochondrial damage-induced apoptosis and inflammation. Dichloroacetate (DCA), a...
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Oyster studies reveal the duplication and functional diversification of Bivalvia caspase-8 genes
Caspase-8, first classified as a pro-apoptotic caspase, is considered to have arisen from duplication with caspase-10 and involves multiple immune...
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Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to TNF-induced death
Caspase-8 (Casp8) serves as an initiator of apoptosis or a suppressor of necroptosis in context-dependent manner. Members of the p90 RSK family can...
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Optogenetic induction of caspase-8 mediated apoptosis by employing Arabidopsis cryptochrome 2
Apoptosis, a programmed cell death mechanism, is a regulatory process controlling cell proliferation as cells undergo demise. Caspase-8 serves as a...
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Caspase-8 activation by cigarette smoke induces pro-inflammatory cell death of human macrophages exposed to lipopolysaccharide
Cigarette smoking impairs the lung innate immune response making smokers more susceptible to infections and severe symptoms. Dysregulation of cell...
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Influenza A virus infection activates caspase-8 to enhance innate antiviral immunity by cleaving CYLD and blocking TAK1 and RIG-I deubiquitination
Caspase-8, an aspartate-specific cysteine protease that primarily functions as an initiator caspase to induce apoptosis, can downregulate innate...
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ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1
Necroptosis is a lytic form of cell death that is mediated by the kinase RIPK3 and the pseudokinase MLKL when caspase-8 is inhibited downstream of...
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A rare immunological disease, caspase 8 deficiency: case report and literature review
BackgroundCaspase-8 is a molecule in the FAS pathway that initiates apoptosis. One of the rarest autoimmune lymphoproliferative syndromes is...
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SIGIRR-caspase-8 signaling mediates endothelial apoptosis in Kawasaki disease
BackgroundKawasaki disease (KD) is a kind of vasculitis with unidentified etiology. Given that the current diagnosis and therapeutic strategy of KD...
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Caspase-8 as a novel mediator linking Src kinase signaling to enhanced glioblastoma malignancy
Caspase-8 is a cysteine protease that plays an essential role in apoptosis. Consistently with its canonical proapoptotic function, cancer cells may...
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Reduced graphene oxide quenched peptide probe for caspase-8 activity detection and cellular imaging
Cysteinyl aspartate-specific protease 8 (caspase-8) plays a key role in various biological processes by regulating apoptosis. Therefore, this makes...
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Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria
Caspase-8 transduces signals from death receptor ligands, such as tumor necrosis factor, to drive potent responses including inflammation, cell...
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Caspase-8 is required for HSV-1-induced apoptosis and promotes effective viral particle release via autophagy inhibition
Regulated cell death (RCD) plays an important role in the progression of viral replication and particle release in cells infected by herpes simplex...
