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p53 and Ferroptosis
Ferroptosis is a form of oxidative cell death that relies on intracellular iron accumulation and lipid peroxidation. Recent studies have shown that...
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Amyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is a malignant tumor that is highly prevalent in Southeast Asia, especially in South China. The pathogenesis of NPC is...
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DCAF13 inhibits the p53 signaling pathway by promoting p53 ubiquitination modification in lung adenocarcinoma
BackgroundLung cancer is a malignant tumor with the highest mortality worldwide. Abnormalities in the ubiquitin proteasome system are considered to...
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Role of p53 in Medulloblastoma Development
p53 is a guardian of the genome because it provides it with stability (Toufektchan and Toledo 2018). It is known as tumor suppressor gene (Surget et...
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PHLDA1 is a P53 target gene involved in P53-mediated cell apoptosis
Pleckstrin homeolike domain, family A, member 1 (PHLDA1) is a multifunctional protein that plays diverse roles in A variety of biological processes,...
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Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts
The p53 tumor suppressor, encoded by the TP53 gene, serves as a major barrier against malignant transformation. Patients with Li-Fraumeni syndrome...
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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity
Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor...
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In-silico Evaluation of Structurally Homologous Drosophila p53 with Human p53 to Identify Functional Differences for Future Therapeutic Research
Abstractp53 is a transcription factor, which is encoded by the TP53 gene in human. p53 regulates the cell cycle and functions as a tumour suppressor,...
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Thermal stress, p53 structures and learning from elephants
As species adapt to climatic changes, temperature-dependent functions of p53 in development, metabolism and cancer will adapt as well. Structural...
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Structural basis of p53 inactivation by cavity-creating cancer mutations and its implications for the development of mutant p53 reactivators
The cavity-creating p53 cancer mutation Y220C is an ideal paradigm for developing small-molecule drugs based on protein stabilization. Here, we have...
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p53 at the crossroads of tumor immunity
The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and consequences that impact diverse cell types and tissues. Recent...
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Targeting tumor suppressor p53 for organ fibrosis therapy
Fibrosis is a reparative and progressive process characterized by abnormal extracellular matrix deposition, contributing to organ dysfunction in...
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Determinants of p53 DNA binding, gene regulation, and cell fate decisions
The extent to which transcription factors read and respond to specific information content within short DNA sequences remains an important question...
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Genetic heterogeneity in p53-null leukemia increases transiently with spindle assembly checkpoint inhibition and is not rescued by p53
Chromosome gains or losses often lead to copy number variations (CNV) and loss of heterozygosity (LOH). Both quantities are low in hematologic...
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The RioK1 network determines p53 activity at multiple levels
By responding to a host of adverse conditions, ranging from DNA damage to viral infection, transcription factor p53 supports genomic stability,...
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Translating p53-based therapies for cancer into the clinic
Inactivation of the most important tumour suppressor gene TP53 occurs in most, if not all, human cancers. Loss of functional wild-type p53 is...
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The Role of p53 in HIV Infection
Purpose of ReviewThis review aims to elucidate the multifaceted role of the tumor suppressor protein p53 in the context of HIV infection. We explore...
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p53 rapidly restructures 3D chromatin organization to trigger a transcriptional response
Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular response to stress. However, the molecular mechanisms...
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P53, ROS: Redox Regulation Signaling, Metabolic Reprogramming, and Autophagy in Cancer
This chapter entitled “P53, ROS-Redox Regulation Signaling, Metabolic Reprogramming, and Autophagy in Cancer” initially shows P53 regulation with...