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Lazy neutrophils – a lack of DGAT1 reduces the chemotactic activity of mouse neutrophils
BackgroundNeutrophils are key players in the innate immune system, actively migrating to sites of inflammation in the highly energetic process of...
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Neutrophils in Atopic Dermatitis
Neutrophils have a critical role in inflammation. Recent studies have identified their distinctive presence in certain types of atopic dermatitis...
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Bilirubin Crystals in Neutrophils
Neutrophils on peripheral smear provide subtle findings or clues to the diagnosis of haematological disorders. The presence of toxic granules,...
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Piezo1 expression in neutrophils regulates shear-induced NETosis
Neutrophil infiltration and subsequent extracellular trap formation (NETosis) is a contributing factor in sterile inflammation. Furthermore,...
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Neutrophils in cancer: dual roles through intercellular interactions
Neutrophils, the most abundant immune cells in human blood, play crucial and diverse roles in tumor development. In the tumor microenvironment (TME),...
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Neutrophils: from IBD to the gut microbiota
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract that results from dysfunction in innate and/or...
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Single-cell analysis defines highly specific leukemia-induced neutrophils and links MMP8 expression to recruitment of tumor associated neutrophils during FGFR1 driven leukemogenesis
BackgroundLeukemias driven by activated, chimeric FGFR1 kinases typically progress to AML which have poor prognosis. Mouse models of this syndrome...
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The role of neutrophils in chronic cough
Chronic cough is a common disorder lasting more than 8 weeks and affecting all age groups. The evidence supporting the role of neutrophils in chronic...
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Neutrophils in Cancer immunotherapy: friends or foes?
Neutrophils play a Janus-faced role in the complex landscape of cancer pathogenesis and immunotherapy. As immune defense cells, neutrophils release...
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Neutrophils in Inflammatory Bone Diseases
Purpose of ReviewIn this review, we summarize the current evidence that suggests that neutrophils play a key role in facilitating damage to local...
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Clearance of apoptotic cells by neutrophils in inflammation and cancer
When a cell dies of apoptosis, it is eliminated either by neighbouring cells or by attracted professional phagocytes. Although it was generally...
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Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy
Tumour-associated neutrophils can exert antitumour effects but can also assume a pro-tumoural phenotype in the immunosuppressive tumour...
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Neutrophils Are Atypical Antigen-Presenting Cells
AbstractNeutrophils are the most numerous blood leukocytes and are the “first line” of defense against pathogens in the focus of inflammation, where...
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Inhibition of CEACAM1 expression in cytokine-activated neutrophils using JAK inhibitors
ObjectivesCarcinoembryonic-antigen-related cell-adhesion molecule 1 (CEACAM1) is an adhesion molecule that acts as a coinhibitory receptor in the...
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Neutrophils
Neutrophilia is considered a typical feature of type 1 or type 17 inflammation and has therefore been associated with CRSsNP, Asian CRSwNP, and...
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Dual role of CD177 + neutrophils in inflammatory bowel disease: a review
Inflammatory bowel disease (IBD) represents a group of recurrent chronic inflammatory disorders associated with autoimmune dysregulation, typically...
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A key regulator of tumor-associated neutrophils: the CXCR2 chemokine receptor
In recent years, with the advance of research, the role of tumor-associated neutrophils (TANs) in tumors has become a research hotspot. As important...
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Obesity-associated microbiomes instigate visceral adipose tissue inflammation by recruitment of distinct neutrophils
Neutrophils are increasingly implicated in chronic inflammation and metabolic disorders. Here, we show that visceral adipose tissue (VAT) from...
