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Mikrobiologisches Gedächtnis: NGS-Untersuchungen in der Archäologie
Whereas the DNA of humans has been in focus of archaeological research since some decades, the composition of soil bacterial communities attracts...
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Standards of NGS Data Sharing and Analysis in Ataxias: Recommendations by the NGS Working Group of the Ataxia Global Initiative
The Ataxia Global Initiative (AGI) is a worldwide multi-stakeholder research platform to systematically enhance trial-readiness in degenerative...
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NGS-Based Biomarkers in Livestock
Introduction of high-throughput molecular technologies and associated bioinformatic tools that potentially made scientists to acquire, process, and...
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Benchmarking NGS-Based HLA Typing Algorithms
Knowledge of the expected accuracy of HLA typing algorithms is important when choosing between algorithms and when evaluating the HLA typing...
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MICROBIAL GENOMICS- the Changing Technological Landscape of Microbiology via NGS
Next-generation sequencing (NGS) methodologies has transformed the landscape of microbiological practice through their capacity to facilitate...
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A review on advancements in feature selection and feature extraction for high-dimensional NGS data analysis
Recent advancements in biomedical technologies and the proliferation of high-dimensional Next Generation Sequencing (NGS) datasets have led to...
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Review of the technology used for structural characterization of the GMO genome using NGS data
The molecular characterization of genetically modified organisms (GMOs) is essential for ensuring safety and gaining regulatory approval for...
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altAFplotter: a web app for reliable UPD detection in NGS diagnostics
BackgroundThe detection of uniparental disomies (the inheritance of both chromosome homologues from a single parent, UPDs) is not part of most...
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RFGR: Repeat Finder for Complete and Assembled Whole Genomes and NGS Reads
Repetitive DNA sequences cause genomic instability and are important genetic markers. Identification of repeats is a critical step in genome...
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MAC-ErrorReads: machine learning-assisted classifier for filtering erroneous NGS reads
BackgroundThe rapid advancement of next-generation sequencing (NGS) machines in terms of speed and affordability has led to the generation of a...
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Benchmarking of bioinformatics tools for NGS-based microRNA profiling with RT-qPCR method
MicroRNAs are vital gene expression regulators, extensively studied worldwide. The large-scale characterization of miRNAomes is possible using...
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Assembly, Annotation and Visualization of NGS Data
The next-generation sequencing technologies have revolutionized the field of agriculture with the advent of ever-evolving chemistries and a reduction...
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Diagnostic Yield of NGS Tests for Hereditary Ataxia: a Systematic Review
Next-generation sequencing (NGS), comprising targeted panels (TP), exome sequencing (ES), and genome sequencing (GS) became robust clinical tools for...
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Enhancing mutation detection in multiple myeloma with an error-corrected ultra-sensitive NGS assay without plasma cell enrichment
BackgroundRisk stratification in multiple myeloma (MM) patients is crucial, and molecular genetic studies play a significant role in achieving this...
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Amplicon-Based Bisulfite Conversion-NGS DNA Methylation Analysis Protocol
DNA methylation is an important epigenetic modification that regulates chromatin structure and the cell-type-specific expression of genes. The...
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Validation of a novel NGS based BCR::ABL1 kinase domain mutation detection assay in Indian cohort
The efficacy and treatment outcome of a CML patient are heavily dependent on BCR::ABL1 kinase domain (KD) mutation status. Next-generation sequencing...
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Applications of NGS Technology in Forensic DNA Analysis
New technology is being applied to forensic DNA analysis to move samples from collection at the crime scene, to sampling, extraction of DNA, and...
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NGS-defined measurable residual disease (MRD) after initial chemotherapy as a prognostic biomarker for acute myeloid leukemia
Treated AML patients often have measurable residual disease (MRD) due to persisting low-level clones. This study assessed whether residual...
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Tumor mutational burden assessment and standardized bioinformatics approach using custom NGS panels in clinical routine
BackgroundHigh tumor mutational burden (TMB) was reported to predict the efficacy of immune checkpoint inhibitors (ICIs). Pembrolizumab, an...
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Genomic profiling of NGS-based ctDNA from Chinese non-small cell lung cancer patients
PurposeCell-free circulating tumor DNA (ctDNA) in plasma enables rapid and repeat testing of actionable mutations. Next-generation sequencing (NGS)...
