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Hyaluronan Structure, Biology and Biotechnology
This book addresses the structural and biological properties of the extracellular matrix component and glycosaminoglycan polymer hyaluronan (or...
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In Vitro Investigation of Hyaluronan/CD44 Network
Hyaluronan is one of the most influential components of the extracellular matrix. It is involved in the regulation of normal tissue function and...
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Role of endothelial hyaluronan in peritoneal membrane transport and disease conditions during peritoneal dialysis
Peritoneal membrane dysfunction in peritoneal dialysis (PD) is primarily attributed to angiogenesis; however, the integrity of vascular endothelial...
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Hyaluronan Metabolism and Tumor Progression
AbstractHereditary and somatic mutations initiating the origin of cancer cells are the key but not the only factor of tumor progression. Activation...
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Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo
Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent...
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Proteoglycans: A Tool for Detecting Hyaluronan by ELISA-Like Methods
Hyaluronan is a non-sulfated glycosaminoglycan synthesized on the plasma membrane of almost all mammalian cells, which can interact with different...
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Biochemistry of Hyaluronan Synthesis
Hyaluronan (HA) is a ubiquitous component of the extracellular matrix and cell microenvironment made of β D-Glucuronic acid and...
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Biocompatible topical delivery system of high-molecular-weight hyaluronan into human stratum corneum using magnesium chloride
Non-invasive delivery of hyaluronan into the stratum corneum (SC) is extremely difficult because of its high molecular weight and the strong barrier...
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The roles of hyaluronan in kidney development, physiology and disease
The hyaluronan (HA) matrix in the tissue microenvironment is crucial for maintaining homeostasis by regulating inflammatory signalling,...
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Fluid restrictive resuscitation with high molecular weight hyaluronan infusion in early peritonitis sepsis
Sepsis is a condition with high morbidity and mortality. Prompt recognition and initiation of treatment is essential. Despite forming an integral...
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Hyaluronan in Kidney Fibrosis
The kidney is the organ responsible for the regulation of the body’s fluid balance. Hyaluronan (HA), because of its unique hydration capacity, is...
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Tissue Slice Culture and Analysis of Tumor-Associated Hyaluronan in Urothelial Carcinoma
Hyaluronan is a major component of the extracellular matrix in both normal and tumor tissue. Many solid cancers, including bladder cancer, are...
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Fluid bolus increases plasma hyaluronan concentration compared to follow-up strategy without a bolus in oliguric intensive care unit patients
Fluid therapy is a fundamental part of supportive therapy in critical care. However, it is also a suspected risk for endothelial glycocalyx...
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Long Noncoding RNAs and Epigenetic Regulation of Hyaluronan Synthesis
Hyaluronan (HA) is a ubiquitous glycosaminglycan of exracellular matrix, whose synthesis is due to the activity of three transmembrane isoenzymes...
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Differential expression analysis identifies a prognostically significant extracellular matrix–enriched gene signature in hyaluronan-positive clear cell renal cell carcinoma
Hyaluronan (HA) accumulation in clear cell renal cell carcinoma (ccRCC) is associated with poor prognosis; however, its biology and role in...
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Exploiting Hyaluronan-CD44 Network in Tumor Therapy
Cancer is one of the leading causes of death worldwide. During tumor development and progression, extracellular matrix is being intensively...
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High-Level Extracellular Expression of Hyaluronate Lyase HylP in Bacillus subtilis for Hyaluronan Degradation
Hyaluronate lyase (HA lyase) has potential in the industrial processing of hyaluronan. In this study, HylP, an HA lyase from Streptococcus pyogenes ...
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Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance and possibly to the longevity of the longest-lived rodent—the...
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Mesenchymal stromal cells confer breast cancer doxorubicin resistance by producing hyaluronan
Chemotherapy resistance represents a major cause of therapeutic failure and mortality in cancer patients. Mesenchymal stromal cells (MSCs), an...
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Apple Pomace Extract Induces Cell Proliferation and Increases Type I Collagen and Hyaluronan Production in Human Skin Fibroblasts In Vitro
Apple pomace is the residue left after apples are squeezed. The majority of pomace produced worldwide is produced by the apple manufacturing...
