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CD33 and CD33-Related Siglecs in Pathogen Recognition and Endocytosis of DC in the Innate Immune System
CD33 is a myeloid differentiation marker antigen with immune functions associated with anti-inflammatory signaling, cell adhesion, and endocytosis....
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Sialic Acid-Binding Ig-Like Lectins (Siglecs)
During the mid-1980s, in vitro rosette formation between macrophages and sheep erythrocytes was reported; however, sialidase treatment on...
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Regulation of prognosis-related Siglecs in the glioma microenvironment
PurposeThe anti-inflammatory environment of glioma reduces the efficacy of immunotherapies. Therefore, it is vital to transform the immunosuppressive...
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CD33 as a leukocyte-associated marker expressed on human spermatozoa
ObjectiveSialic acid-binding immunoglobulin-type lectins (Siglecs) are commonly present on immune cells and often mediate cell-to-cell interactions...
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The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
Carbohydrates — namely glycans — decorate every cell in the human body and most secreted proteins. Advances in genomics, glycoproteomics and tools...
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Impact of the Siglec-Sialoglycan Axis on the Cancer Immune Response
Sialic acid-binding immunoglobulin-like lectins (Siglecs) have heavily mediated the tumour landscape and shown significant deregulation in many...
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Siglecs at the Host–Pathogen Interface
Siglecs are sialic acid (Sia) recognizing immunoglobulin-like receptors expressed on the surface of all the major leukocyte lineages in mammals....
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Identification of therapeutic targets and prognostic biomarkers in the Siglec family of genes in tumor immune microenvironment of sarcoma
Sarcomas (SARC) are a highly heterogeneous cancer type that is prone to recurrence and metastasis. Numerous studies have confirmed that Siglecs are...
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Gangliosides as Siglec ligands
The structure of a sialoglycan can be translated into to a biological response when it binds to a specific endogenous lectin. Among endogenous sialic...
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Siglecs that Associate with DAP12
Siglecs are a family of transmembrane receptor-like glycan-recognition proteins expressed primarily on leukocytes. Majority of Siglecs have an...
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Substantial Basis for Glyco-Assembly: Siglec7 and Synthetic Sialylpolymers
Sialic acid is one of the tags that are recognized as “self,” when immune cells survey “non-self” items using the sialic acid-recognizing lectins,...
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The intriguing roles of Siglec family members in the tumor microenvironment
Sialic acid-binding receptors are expressed on the surfaces of a variety of immune cells and have complex and diverse immunoregulatory functions in...
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Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells
Mast cells (MC) are key drivers of allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-6 is an...
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Identification and validation of a siglec-based and aging-related 9-gene signature for predicting prognosis in acute myeloid leukemia patients
BackgroundAcute myeloid leukemia (AML) is a group of highly heterogenous and aggressive blood cancer. Despite recent progress in its diagnosis and...
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Sialic acid–binding immunoglobulin-like lectins (Siglecs) detect self-associated molecular patterns to regulate immune responses
The mammalian immune system evolved to tightly regulate the elimination of pathogenic microbes and neoplastic transformed cells while tolerating our...
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Microglial TYROBP/DAP12 in Alzheimer’s disease: Transduction of physiological and pathological signals across TREM2
TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially described as a receptor-activating subunit component of natural...
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Cancer-derived sialylated IgG promotes tumor immune escape by binding to Siglecs on effector T cells
To date, IgG in the tumor microenvironment (TME) has been considered a product of B cells and serves as an antitumor antibody. However, in this...
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Relationships of SIGLEC family-related lncRNAs with clinical prognosis and tumor immune microenvironment in ovarian cancer
Long non-coding RNAs (lncRNAs) and Sialic acid-binding immunoglobulin-type lectin (SIGLEC) family members play an important role in proliferation,...
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Targeting CD24/Siglec-10 signal pathway for cancer immunotherapy: recent advances and future directions
The small, heavily glycosylated protein CD24 is primarily expressed by many immune cells and is highly expressed mostly in cancer cells. As one of...
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Whole-cell tumor vaccines desialylated to uncover tumor antigenic Gal/GalNAc epitopes elicit anti-tumor immunity
BackgroundAberrant sialoglycans on the surface of tumor cells shield potential tumor antigen epitopes, escape recognition, and suppress activation of...
